SynthesisLangenbeck's archives of surgery2017
Systemic inflammatory response after hernia repair: a systematic review.
Synthesis in Langenbeck's archives of surgery, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06380140 (Relationship Between Acute Phase Markers and Post-operative Pain in Open Tension-free Inguinal Hernia Repair), which is not on this map. Cited by 17 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Relationship Between Acute Phase Markers and Post-operative Pain in Open Tension-free Inguinal Hernia Repair: An Observational Study
Who cites it
17 citing papers in PubMed, 3 syntheses or guidelines pooled it, 46 citations in OpenAlex.
- Autoimmunity and hernia mesh: fact or fiction?Hernia : the journal of hernias and abdominal wall surgery · 2023Pooled it
- Are polypropylene mesh implants associated with systemic autoimmune inflammatory syndromes? A systematic review.Hernia : the journal of hernias and abdominal wall surgery · 2022Pooled it
- Effect of non-surgical periodontal therapy on renal function in chronic kidney disease patients with periodontitis: a systematic review and meta-analysis of interventional studies.Clinical oral investigations · 2020Pooled it
- The effect of dexmedetomidine premedication on postoperative systemic inflammatory response in children undergoing hernia repair surgery: A randomized controlled trial.Paediatric anaesthesia · 2021Trial
- Systemic Stress Biomarkers and Patient-Reported Outcomes Following Laparoscopic IPOM+ and Open Rives-Stoppa Repair for Ventral Incisional Hernia: A Prospective Non-Randomized Comparative Study.Journal of clinical medicine · 2026Article
- The effect of unilateral inguinal hernia surgery performed at different times of the day on inflammation and recovery: a prospective randomized controlled study.Updates in surgery · 2026Article
- ECM Remodeling in Direct Inguinal Hernia: The Role of Aging, Oxidative Stress, and Antioxidants Defenses.Clinics and practice · 2025Review
- A Comparative Metabolomics Study of Multiple Urological Diseases by Highly Sensitive Dansylation Isotope Labeling LC-MS.International journal of molecular sciences · 2025Article
- Lactate in Drainage Fluid to Predict Complications in Robotic Esophagectomies-A Pilot Study in a Matched Cohort.Journal of clinical medicine · 2025Article
- Chronic inflammation following hernia repair and cancer risk: A nationwide study.Surgery open science · 2025Article
- Self-gripping versus polypropylene mesh for incisional hernia repair in a rat model.Surgical endoscopy · 2025Article
- Causal relationship between circulating inflammatory cytokines and the risk of hernia: a bidirectional Mendelian randomization study.The Journal of international medical research · 2025Article
- Effect of Laparoscopic Inguinal Hernia Repairs on Inflammatory Factors, Oxidative Stress Levels and Postoperative Recovery.Journal of inflammation research · 2024Article
- C-Reactive Protein as Predictor for Infectious Complications after Robotic and Open Esophagectomies.Journal of clinical medicine · 2022Article
- Serum C-reactive protein and iron levels following gonadectomy are not modified by perioperative administration of robenacoxib to dogs.Canadian journal of veterinary research = Revue canadienne de recherche veterinaire · 2022Article
- Serum C-reactive protein level after ventral hernia repair with mesh reinforcement can predict infectious complications: a retrospective cohort study.Hernia : the journal of hernias and abdominal wall surgery · 2020Article
- Polypropylene mesh and systemic side effects in inguinal hernia repair: current evidence.Irish journal of medical science · 2019Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeAll surgical procedures elicit a complex systemic inflammatory response effectuated and modulated by cytokines. The purpose of this systematic review was to present an overview of the inflammatory response and the serum markers associated with hernia repair and to compare the response between patients treated with and without mesh.
methodsThe review was conducted in line with PRISMA guidelines. The outcomes of interest were serum concentration of leukocytes, cytokines, and acute phase proteins before and after hernia repair with or without mesh reinforcement. The risk of bias was assessed using the Cochrane ROBINS-I tool for non-randomized studies of intervention.
resultsA total of 31 studies were included in the systematic review including 1326 patients with a mean age ranging from 33 to 67 years. The studies predominantly included males (95.0% males, 5.0% female) with inguinal hernias (98.5% inguinal hernias, 1.5% incisional hernias). The inflammatory response after hernia repair was characterized by an increase in CRP, IL-6, leukocytes, neutrophils, IL-1, IL-10, fibrinogen, and α1-antitrypsin and a decrease in lymphocytes and albumin within the first 24 postoperative hours. The systemic inflammatory response was normalized before or on the seventh postoperative day. A higher CRP and IL-6 serum concentration was found in patients treated with mesh compared with sutured repairs.
conclusionsHernia repair elicits a systemic inflammatory response characterized by an increase in CRP, IL-6, leukocytes, neutrophils, IL-1, IL-10, fibrinogen, and α1-antitrypsin and a decrease in lymphocytes and albumin. A higher inflammatory response was found after mesh repair compared with non-mesh repair and after open mesh repair compared with laparoscopic mesh repair.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.