ArticleInternational journal of nanomedicine2017
Development of a novel microemulsion for oral absorption enhancement of all-trans retinoic acid.
Article in International journal of nanomedicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed.
- Activating RARβ to overcome immunomodulatory drug resistance in t(4;14) human myeloma.Leukemia · 2026Article
- Food-Grade Microemulsion for High-Loading Octacosanol: Formulation Optimization, Characterization, and Biological Evaluation.Foods (Basel, Switzerland) · 2026Article
- Simplex Lattice Design and Machine Learning Methods for the Optimization of Novel Microemulsion Systems to Enhance p-Coumaric Acid Oral Bioavailability: In Vitro and In Vivo Studies.AAPS PharmSciTech · 2024Article
- Novel Microemulsion Containing Benzocaine and Fusidic Acid Simultaneously: Formulation, Characterization, and In Vitro Evaluation for Wound Healing.AAPS PharmSciTech · 2024Article
- Quality-by-design-based microemulsion of disulfiram for repurposing in melanoma and breast cancer therapy.Therapeutic delivery · 2024Article
- Oral administration of Huanglian-Houpo herbal nanoemulsion loading multiple phytochemicals for ulcerative colitis therapy in mice.Drug delivery · 2023Article
- Sustained release gel (polymer-free) of itraconazole-loaded microemulsion for oral candidiasis treatment: time-kill kinetics and cellular uptake.Drug delivery · 2023Article
- Tackling acne vulgaris by fabrication of tazarotene-loaded essential oil-based microemulsion:International journal of pharmaceutics: X · 2023Article
- Topical Microemulsions: Skin Irritation Potential and Anti-Inflammatory Effects of Herbal Substances.Pharmaceuticals (Basel, Switzerland) · 2023Review
- Propranolol-Loaded Limonene-Based Microemulsion Thermo-Responsive Mucoadhesive Nasal Nanogel: Design, In Vitro Assessment, Ex Vivo Permeation, and Brain Biodistribution.Gels (Basel, Switzerland) · 2023Article
- Optimization of Delivery and Bioavailability of Encapsulated Caffeic Acid.Foods (Basel, Switzerland) · 2023Article
- Dissolution Improvement of Progesterone and Testosterone via Impregnation on Mesoporous Silica Using Supercritical Carbon Dioxide.AAPS PharmSciTech · 2022Article
- Design of GSH-Responsive Curcumin Nanomicelles for Oesophageal Cancer Therapy.Pharmaceutics · 2022Article
- Emulgels ContainingPolymers · 2022Article
- Microemulsion Delivery System Improves Cellular Uptake of Genipin and Its Protective Effect against Aβ1-42-Induced PC12 Cell Cytotoxicity.Pharmaceutics · 2022Article
- DPD Simulation on the Transformation and Stability of O/W and W/O Microemulsions.Molecules (Basel, Switzerland) · 2022Article
- Surface Modification of Curcumin Microemulsions by Coupling of KLVFF Peptide: A Prototype for Targeted Bifunctional Microemulsions.Polymers · 2022Article
- Enhancement of the Topical Bioavailability and Skin Whitening Effect of Genistein by Using Microemulsions as Drug Delivery Carriers.Pharmaceuticals (Basel, Switzerland) · 2021Article
- A practical strategy to subcutaneous administeredAsian journal of pharmaceutical sciences · 2021Article
- Recent Technologies for Amorphization of Poorly Water-Soluble Drugs.Pharmaceutics · 2021Review
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This study was aimed to develop a novel microemulsion that contained oleth-5 as a surfactant to enhance the oral absorption of all-trans retinoic acid (ATRA). The prepared microemulsion was evaluated for its particle size, shape, zeta potential, in vitro release, in vitro intestinal absorption, intestinal membrane cytotoxicity and stability. The obtained microemulsion was spherical in shape with a particle size of <200 nm and a negative surface charge. The in vitro release of the ATRA-loaded microemulsion was best fit with the zero-order model. This microemulsion significantly improved the intestinal absorption of ATRA. Confocal laser scanning microscopy analysis using a fluorescent dye-loaded microemulsion also confirmed the intestinal absorption result. The intestinal membrane cytotoxicity of the ATRA-loaded microemulsion did not differ from an edible oil (fish oil). Stability testing showed that the ATRA-loaded microemulsion was more stable at 25°C than 40°C.
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