ArticleMolecular psychiatry2017
Methamphetamine abuse impairs motor cortical plasticity and function.
Article in Molecular psychiatry, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.
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Who cites it
44 citing papers in PubMed.
- Bilateral theta-burst magnetic stimulation influence on event-related brain potentials.PloS one · 2018Trial
- Heightened excitability and impaired Inhibition in methamphetamine users: a pilot study of neurophysiological correlates of psychological symptoms.Psychopharmacology · 2026Article
- Discrete interneuron subsets participate in GluN1/GluN3A excitatory glycine receptor (eGlyR)-mediated regulation of hippocampal network activity throughout development and evolution.Research square · 2025Article
- Discrete interneuron subsets participate in GluN1/GluN3A excitatory glycine receptor (eGlyR)-mediated regulation of hippocampal network activity throughout development and evolution.bioRxiv : the preprint server for biology · 2025Article
- Differential Gene Expression in the Prefrontal Cortex and Hippocampus Following Long-Access Methamphetamine Self-Administration in Male Rats.International journal of molecular sciences · 2025Article
- Cortical plasticity differences in substance use disorders.Fundamental research · 2024Article
- Exploring amygdala structural changes and signaling pathways in postmortem brains: consequences of long-term methamphetamine addiction.Anatomy & cell biology · 2024Article
- The effect of detoxification on acoustic features of Mandarin speech in male heroin users.PloS one · 2024Article
- The Common Denominators of Parkinson's Disease Pathogenesis and Methamphetamine Abuse.Current neuropharmacology · 2024Review
- Methodological approach for assessing motor cortical excitability changes with single-pulse transcranial magnetic stimulation.MethodsX · 2023Article
- An unconventional cancer-promoting function of methamphetamine in hepatocellular carcinoma.Life science alliance · 2023Article
- SYNCRIP controls miR-137 and striatal learning in animal models of methamphetamine abstinence.Acta pharmaceutica Sinica. B · 2022Article
- Methamphetamine augments HIV-1 gp120 inhibition of synaptic transmission and plasticity in rat hippocampal slices: Implications for methamphetamine exacerbation of HIV-associated neurocognitive disorders.Neurobiology of disease · 2022Article
- Methamphetamine: burden, mechanism and impact on pregnancy, the fetus, and newborn.Journal of perinatology : official journal of the California Perinatal Association · 2022Review
- Footshock-Induced Abstinence from Compulsive Methamphetamine Self-administration in Rat Model Is Accompanied by Increased Hippocampal Expression of Cannabinoid Receptors (CB1 and CB2).Molecular neurobiology · 2022Article
- Potential Effects of Nrf2 in Exercise Intervention of Neurotoxicity Caused by Methamphetamine Oxidative Stress.Oxidative medicine and cellular longevity · 2022Review
- Intermittent Theta Burst Stimulation vs. High-Frequency Repetitive Transcranial Magnetic Stimulation in the Treatment of Methamphetamine Patients.Frontiers in psychiatry · 2022Article
- Effects of methamphetamine-induced neurotoxicity on striatal long-term potentiation.Psychopharmacology · 2022Article
- Article
- Control of protein synthesis and memory by GluN3A-NMDA receptors through inhibition of GIT1/mTORC1 assembly.eLife · 2021Article
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14 authors.
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No grant is acknowledged in the PubMed record.
Abstract
Exposure to addictive drugs triggers synaptic plasticity in reward-related brain regions, such as the midbrain, nucleus accumbens and the prefrontal cortex. Effects of chronic drug exposure on other brain areas have not been fully investigated. Here, we characterize synaptic plasticity in motor cortex after methamphetamine self-administration in rats. We show that this causes a loss of corticostriatal plasticity in rat brain slices and impaired motor learning in the rotarod task. These findings are paralleled by the observation of a lack of transcranial magnetic stimulation-induced potentiation or depression of motor evoked potentials in human patients with addiction, along with poor performance in rotary pursuit task. Taken together, our results suggest that chronic methamphetamine use can affect behavioral performance via drug-evoked synaptic plasticity occluding physiological motor learning.
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