Evidence map›Paper›PMID 28831138›Full record

ArticleScientific reports2017

Embryonic hindbrain patterning genes delineate distinct cardio-respiratory and metabolic homeostatic populations in the adult.

Jenny J Sun, Teng-Wei Huang, Jeffrey L Neul, Russell S Ray

Abstract read
In one paragraph

Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Jenny J SunDepartment of Neuroscience, Baylor College of Medicine, Houston, Texas, USA.
Teng-Wei HuangCenter for Cell and Gene Therapy, Baylor College of Medicine, Houston, Texas, USA.
Jeffrey L NeulDepartment of Neuroscience, Baylor College of Medicine, Houston, Texas, USA.
Russell S RayDepartment of Neuroscience, Baylor College of Medicine, Houston, Texas, USA. russell.ray@bcm.edu.ORCID 0000-0001-9610-2703

Funding

Noradrenergic mechanisms in breathing and respiratory pathophysiologiesR01HL130249 · NHLBI · BAYLOR COLLEGE OF MEDICINE · PI RAY, RUSSELL S · 2016 to 2024
$5.3M
Characterizing autonomic dysfunction in Rett syndrome and other MECP2 disordersR01HD062553 · NICHD · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI NEUL, JEFFREY L · 2010 to 2014
$1.7M
NHLBI NIH HHS R01 HL130249NICHD NIH HHS R01 HD062553
6 · The paper itself

Abstract

Previous studies based on mouse genetic mutations suggest that proper partitioning of the hindbrain into transient, genetically-defined segments called rhombomeres is required for normal respiratory development and function in neonates. Less clear is what role these genes and the neurons they define play in adult respiratory circuit organization. Several Cre drivers are used to access and study developmental rhombomeric domains (Eng1

Indexed as

HomeostasisTranscriptomeAge FactorsAnimalsEnergy MetabolismGene Expression ProfilingMiceMyocardiumNeuronsPhenotypeRespiratory SystemRhombencephalon

Identifiers

PMID28831138
PMCPMC5567350

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.