ArticleScientific reports2017
Associations between lead concentrations and cardiovascular risk factors in U.S. adolescents.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
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Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it, 33 citations in OpenAlex.
- Toxic metal exposure as a possible risk factor for COVID-19 and other respiratory infectious diseases.Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association · 2020Pooled it
- Potential Antidote Against Lead Toxicity-A Review.International journal of molecular sciences · 2026Review
- The Impact of Arsenic, Cadmium, Lead, Mercury, and Thallium Exposure on the Cardiovascular System and Oxidative Mechanisms in Children.Current issues in molecular biology · 2025Review
- Associations of per- and polyfluoroalkyl substances and heavy metals with blood lipid profiles in a representative sample of Korean adolescents.Environmental health : a global access science source · 2024Article
- Effects of Blood Lead Levels <10 µg/dL in School-Age Children and Adolescents: A Scoping Review.Pediatrics · 2024Article
- Disturbed Ratios between Essential and Toxic Trace Elements as Potential Biomarkers of Acute Ischemic Stroke.Nutrients · 2023Article
- Potential Health Risks of Lead Exposure from Early Life through Later Life: Implications for Public Health Education.International journal of environmental research and public health · 2022Article
- Mapping the Morbidity Risk Associated with Coal Mining in Queensland, Australia.International journal of environmental research and public health · 2022Article
- Association between serum folate concentrations and blood lead levels in adolescents: A cross-sectional study.Frontiers in pediatrics · 2022Article
- Key Characteristics of Cardiovascular Toxicants.Environmental health perspectives · 2021Article
- The association between serum copper concentrations and elevated blood pressure in US children and adolescents: National Health and Nutrition Examination Survey 2011-2016.BMC cardiovascular disorders · 2021Article
- Modification of vitamin B6 on the associations of blood lead levels and cardiovascular diseases in the US adults.BMJ nutrition, prevention & health · 2020Article
- Article
- Editorial: Exposure to Endocrine-Disrupting Chemicals and Cardiometabolic Disease: A Developmental Origins Approach.Frontiers in public health · 2019Article
- The association between serum copper concentrations and cardiovascular disease risk factors in children and adolescents in NHANES.Environmental science and pollution research international · 2018Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Little is known regarding the effects of environmental lead exposure on cardiovascular risk factors in the adolescent population. We studied 11,662 subjects included in the National Health and Nutrition Examination Survey (NHANES) 1999-2012. Blood lead levels were analysed for their association with cardiovascular risk factors (CVRF). Regression coefficients (Beta) and 95% confidence intervals (CIs) of blood lead in association with CVRF (e.g., total cholesterol, HDL-cholesterol, LDL-cholesterol, triglyceride, fasting glucose, glycohemoglobin, fasting insulin, and blood pressure) were estimated using multivariate and generalized linear regression after adjusting for age, gender, ethnicity, serum cotinine, body mass index (BMI), physical activity, and household income. We identified a strong positive association between blood lead (coefficient = 0.022, 95% CI 0.003, 0.041; P = 0.022) and LDL-cholesterol in adolescents (age 12-19 years). However, no associations with other CVRFs were found in the overall population. In the generalized linear models, participants with the highest lead levels demonstrated a 1.87% (95% CI 0.73%, 3.02%) greater increase in serum LDL-cholesterol (p for trend = 0.031) when compared to participants with the lowest lead levels. These results provide epidemiological evidence that low levels of blood lead are positively associated with LDL-cholesterol in the adolescent population.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.