ArticleScientific reports2017
Dynamic, heterogeneous endothelial Tie2 expression and capillary blood flow during microvascular remodeling.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
13 citing papers in PubMed, 25 citations in OpenAlex.
- Molecular and cellular imaging of the eye.Biomedical optics express · 2024Review
- A versatile vessel casting method for fine mapping of vascular networks using a hydrogel-based lipophilic dye solution.Cell reports methods · 2023Article
- Imaging the construction of capillary networks in the neonatal mouse brain.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Retinal safety evaluation of photoacoustic microscopy.Experimental eye research · 2021Article
- Towards non-contact photoacoustic imaging [review].Photoacoustics · 2020Review
- Glomerular endothelial cell heterogeneity in Alport syndrome.Scientific reports · 2020Article
- Pericyte Bridges in Homeostasis and Hyperglycemia.Diabetes · 2020Article
- Visualization and molecular characterization of whole-brain vascular networks with capillary resolution.Nature communications · 2020Article
- Methods to label, image, and analyze the complex structural architectures of microvascular networks.Microcirculation (New York, N.Y. : 1994) · 2019Review
- Perivascular cell-specific knockout of the stem cell pluripotency gene Oct4 inhibits angiogenesis.Nature communications · 2019Article
- In Vivo 3D Imaging of Retinal Neovascularization Using Multimodal Photoacoustic Microscopy and Optical Coherence Tomography Imaging.Journal of imaging · 2018Article
- Photoacoustic Ophthalmoscopy: Principle, Application, and Future Directions.Journal of imaging · 2018Article
- Klf4 has an unexpected protective role in perivascular cells within the microvasculature.American journal of physiology. Heart and circulatory physiology · 2018Article
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
Abstract
Microvascular endothelial cell heterogeneity and its relationship to hemodynamics remains poorly understood due to a lack of sufficient methods to examine these parameters in vivo at high resolution throughout an angiogenic network. The availability of surrogate markers for functional vascular proteins, such as green fluorescent protein, enables expression in individual cells to be followed over time using confocal microscopy, while photoacoustic microscopy enables dynamic measurement of blood flow across the network with capillary-level resolution. We combined these two non-invasive imaging modalities in order to spatially and temporally analyze biochemical and biomechanical drivers of angiogenesis in murine corneal neovessels. By stimulating corneal angiogenesis with an alkali burn in Tie2-GFP fluorescent-reporter mice, we evaluated how onset of blood flow and surgically-altered blood flow affects Tie2-GFP expression. Our study establishes a novel platform for analyzing heterogeneous blood flow and fluorescent reporter protein expression across a dynamic microvascular network in an adult mammal.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.