ArticleScientific reports2017
Stimulation triggers endogenous activity patterns in cultured cortical networks.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed.
- Article
- Article
- Engineering Neuronal Network Connectivity Through Precise and Scalable Electrical Modulation.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Repetitive training enhances the pattern recognition capability of cultured neural networks.PLoS computational biology · 2025Article
- Stimulus effects of extremely low-frequency electric field exposure on calcium oscillations in a human cortical spheroid.Bioelectromagnetics · 2025Article
- Deviance detection and regularity sensitivity in dissociated neuronal cultures.Frontiers in neural circuits · 2025Article
- Modular architecture confers robustness to damage and facilitates recovery in spiking neural networks modelingFrontiers in neuroscience · 2025Article
- Revealing single-neuron and network-activity interaction by combining high-density microelectrode array and optogenetics.Nature communications · 2024Article
- Engineering anFrontiers in neuroscience · 2024Article
- Biological neurons act as generalization filters in reservoir computing.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Nanomaterial-based microelectrode arrays for in vitro bidirectional brain-computer interfaces: a review.Microsystems & nanoengineering · 2023Review
- Neuromorphic-Based Neuroprostheses for Brain Rewiring: State-of-the-Art and Perspectives in Neuroengineering.Brain sciences · 2022Review
- Stimulus-Evoked Activity Modulation of In Vitro Engineered Cortical and Hippocampal Networks.Micromachines · 2022Article
- Learning populations with hubs govern the initiation and propagation of spontaneous bursts in neuronal networks after learning.Frontiers in neuroscience · 2022Article
- Coupling ofFrontiers in neuroscience · 2022Article
- Spontaneous and Perturbational Complexity in Cortical Cultures.Brain sciences · 2021Article
- Plasticity and Adaptation in Neuromorphic Biohybrid Systems.iScience · 2020Review
- Scale-Free Dynamics in Animal Groups and Brain Networks.Frontiers in systems neuroscience · 2020Article
- Prevention of excitotoxicity-induced processing of BDNF receptor TrkB-FL leads to stroke neuroprotection.EMBO molecular medicine · 2019Article
- Inhomogeneities in Network Structure and Excitability Govern Initiation and Propagation of Spontaneous Burst Activity.Frontiers in neuroscience · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cultures of dissociated cortical neurons represent a powerful trade-off between more realistic experimental models and abstract modeling approaches, allowing to investigate mechanisms of synchronized activity generation. These networks spontaneously alternate periods of high activity (i.e. network bursts) with periods of quiescence in a dynamic state which recalls the fluctuation of in vivo UP and DOWN states. Network bursts can also be elicited by external stimulation and their spatial propagation patterns tracked by means of multi-channel micro-electrode arrays. In this study, we used rat cortical cultures coupled to micro-electrode arrays to investigate the similarity between spontaneous and evoked activity patterns. We performed experiments by applying electrical stimulation to different network locations and demonstrated that the rank orders of electrodes during evoked and spontaneous events are remarkably similar independently from the stimulation source. We linked this result to the capability of stimulation to evoke firing in highly active and "leader" sites of the network, reliably and rapidly recruited within both spontaneous and evoked bursts. Our study provides the first evidence that spontaneous and evoked activity similarity is reliably observed also in dissociated cortical networks.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.