Evidence map›Paper›PMID 28831068›Full record

ArticleScientific reports2017

Synthesis of Nm-PHB (nanomelanin-polyhydroxy butyrate) nanocomposite film and its protective effect against biofilm-forming multi drug resistant Staphylococcus aureus.

George Seghal Kiran, Stephen A Jackson, Sethu Priyadharsini, Alan D W Dobson, Joseph Selvin

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
3.4field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 84 citations in OpenAlex.

  1. Article
  2. Review
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  9. Article
  10. In Vitro and In Vivo Biocompatibility of Natural and SyntheticInternational journal of molecular sciences · 2023
    Article
  11. Review
  12. Review
  13. Article
  14. Article
  15. Review
  16. Melanin production byBiotechnologia · 2021
    Article
  17. Microbial production of melanin and its various applications.World journal of microbiology & biotechnology · 2020
    Review
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 2 countries.

George Seghal KiranDepartment of Food Science and Technology, Pondicherry University, Puducherry, 605014, India. seghalkiran@gmail.com.
Stephen A JacksonSchool of Microbiology, University College Cork, Cork, Ireland.ORCID 0000-0001-7869-9032
Sethu PriyadharsiniDepartment of Food Science and Technology, Pondicherry University, Puducherry, 605014, India.
Alan D W DobsonSchool of Microbiology, University College Cork, Cork, Ireland.
Joseph SelvinDepartment of Microbiology, School of Life Sciences, Pondicherry University, Puducherry, 605014, India.
Pondicherry University · INUniversity College Cork · IE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Melanin is a dark brown ubiquitous photosynthetic pigment which have many varied and ever expanding applications in fabrication of radio-protective materials, food packaging, cosmetics and in medicine. In this study, melanin production in a Pseudomonas sp. which was isolated from the marine sponge Tetyrina citirna was optimized employing one-factor at a time experiments and characterized for chemical nature and stability. Following sonication nucleated nanomelanin (Nm) particles were formed and evaluated for antibacterial and antioxidant properties. Nanocomposite film was fabricated using combinations (% w/v) of polyhydroxy butyrate-nanomelanin (PHB:Nm) blended with 1% glycerol. The Nm was found to be spherical in shape with a diameter of 100-140 nm and showed strong antimicrobial activity against both Gram positive and Gram negative bacteria. The Nm-PHB nanocomposite film was homogeneous, smooth, without any cracks, and flexible. XRD and DSC data indicated that the film was crystalline in nature, and was thermostable up to 281.87 °C. This study represents the first report on the synthesis of Nm and fabrication of Nm-PHB nanocomposite film which show strong protective effect against multidrug resistant Staphyloccoccus aureus. Thus this Nm-PHB nanocomposite film may find utility as packaging material for food products by protecting the food products from oxidation and bacterial contamination.

Indexed as

AnimalsBiofilmsDrug Resistance, Multiple, BacterialFood PackagingHydroxybutyratesMelaninsNanocompositesParticle SizePhylogenyPoriferaPseudomonasStaphylococcus aureusX-Ray DiffractionHydroxybutyratesMelanins

Identifiers

PMID28831068
PMCPMC5567312
OpenAlexW2747870068

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.