ArticleProceedings of the National Academy of Sciences of the United States of America2017
Foldamer hypothesis for the growth and sequence differentiation of prebiotic polymers.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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Who cites it
34 citing papers in PubMed.
- RNA and proteins joined up at the Origins of Life: Persistence is the point.bioRxiv : the preprint server for biology · 2026Article
- Non-enzymatic error correction in self-replicators without extraneous energy supply.Scientific reports · 2026Article
- Evolution from Composome to RNA Replicase.Life (Basel, Switzerland) · 2026Review
- Proteins Rich in Prime Mass Residues and Their Role in Cell Biology.Evolutionary bioinformatics online · 2026Article
- Emergent Chemical Reactivity and Complexity of RNA Condensates.Angewandte Chemie (International ed. in English) · 2025Article
- Science of the gaps.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2025Article
- In silico evolution of globular protein folds from random sequences.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Prime mass amino acids: A new numbers based classification of significance to mass spectrometry and protein biology.European journal of mass spectrometry (Chichester, England) · 2025Article
- Structural Enzymology, Phylogenetics, Differentiation, and Symbolic Reflexivity at the Dawn of Biology.Genome biology and evolution · 2025Article
- On the role of α-alumina in the origin of life: Surface-driven assembly of amino acids.Science advances · 2025Article
- Article
- Origins of Life: The Protein Folding Problem all over again?Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Insights into conformational ensembles of compositionally identical disordered peptidomimetics.Polymer chemistry · 2024Article
- The prebiotic emergence of biological evolution.Royal Society open science · 2024Article
- Mapping Composition Evolution through Synthesis, Purification, and Depolymerization of Random Heteropolymers.Journal of the American Chemical Society · 2024Article
- The intrinsically disordered protein glue of the myelin major dense line: Linking AlphaFold2 predictions to experimental data.Biochemistry and biophysics reports · 2023Article
- Light-Fueled Primitive Replication and Selection in Biomimetic Chemical Systems.Journal of the American Chemical Society · 2023Article
- Origins of life: first came evolutionary dynamics.QRB discovery · 2023Review
- The Bootstrap Model of Prebiotic Networks of Proteins and Nucleic Acids.Life (Basel, Switzerland) · 2022Article
- Improving coarse-grained models of protein folding through weighting of polar-polar/hydrophobic-hydrophobic interactions into crowded spaces.Journal of molecular modeling · 2022Article
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3 authors.
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Abstract
It is not known how life originated. It is thought that prebiotic processes were able to synthesize short random polymers. However, then, how do short-chain molecules spontaneously grow longer? Also, how would random chains grow more informational and become autocatalytic (i.e., increasing their own concentrations)? We study the folding and binding of random sequences of hydrophobic ([Formula: see text]) and polar ([Formula: see text]) monomers in a computational model. We find that even short hydrophobic polar (
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