Evidence map›Paper›PMID 28830947›Full record

ArticlemBio2017

Two Distinct Mechanisms Govern RpoS-Mediated Repression of Tick-Phase Genes during Mammalian Host Adaptation by

Arianna P Grove, Dionysios Liveris, Radha Iyer, Mary Petzke, Joseph Rudman, Melissa J Caimano, Justin D Radolf, Ira Schwartz

Open access · goldAbstract read
In one paragraph

Article in mBio, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed
2.8field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 35 citations in OpenAlex.

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  16. Article
  17. σFrontiers in microbiology · 2021
    Article
  18. Gene Regulation and Transcriptomics.Current issues in molecular biology · 2021
    Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Arianna P GroveDepartment of Microbiology and Immunology, New York Medical College, Valhalla, New York, USA.
Dionysios LiverisDepartment of Microbiology and Immunology, New York Medical College, Valhalla, New York, USA.
Radha IyerDepartment of Microbiology and Immunology, New York Medical College, Valhalla, New York, USA.
Mary PetzkeDepartment of Microbiology and Immunology, New York Medical College, Valhalla, New York, USA.
Joseph RudmanDepartment of Microbiology and Immunology, New York Medical College, Valhalla, New York, USA.
Melissa J CaimanoDepartment of Medicine, UConn Health, Farmington, Connecticut, USA.
Justin D RadolfDepartment of Medicine, UConn Health, Farmington, Connecticut, USA.
Ira SchwartzDepartment of Microbiology and Immunology, New York Medical College, Valhalla, New York, USA Schwartz@nymc.edu.
New York Medical College · USUConn Health · US

Funding

RpoS Regulation of Borrelia burgdorferi Genes in vivoR01AI029735 · NIAID · UNIVERSITY OF TEXAS SW MED CTR/DALLAS · PI CAIMANO, MELISSA J, RADOLF, JUSTIN D · 1990 to 2022
$10.7M
DETERMINANTS OF B BURGDORFERI HEMATOGENOUS DISSEMINATIONR01AI045801 · NIAID · NEW YORK MEDICAL COLLEGE · PI SCHWARTZ, IRA S. · 1999 to 2015
$4.9M
RpoS Regulation of Borrelia burgdorferi Genes in vivoR56AI029735 · NIAID · UNIVERSITY OF CONNECTICUT SCH OF MED/DNT · PI RADOLF, JUSTIN D · 2012 to 2012
$536k
Essential role of Hk1/Rrp1 TCS for survival of Borrelia burgdorferi in ticksR21AI126146 · NIAID · UNIVERSITY OF CONNECTICUT SCH OF MED/DNT · PI CAIMANO, MELISSA J · 2016 to 2017
$439k
NIAID NIH HHS R01 AI029735NIAID NIH HHS R01 AI045801NIAID NIH HHS R21 AI126146NIAID NIH HHS R56 AI029735
6 · The paper itself

Abstract

The alternative sigma factor RpoS plays a key role modulating gene expression in

Indexed as

Adaptation, PhysiologicalGene Expression Regulation, BacterialAnimalsAntigens, BacterialBacterial Outer Membrane ProteinsBacterial ProteinsBorrelia burgdorferiGreen Fluorescent ProteinsHost-Pathogen InteractionsMutationOperonPeritoneal CavityPromoter Regions, GeneticRatsSigma FactorTicksAntigens, BacterialBacterial Outer Membrane ProteinsBacterial ProteinsGreen Fluorescent ProteinsOspB protein, Borrelia burgdorferiSigma Factorsigma factor KatF protein, BacteriaBorrelia burgdorferiLyme diseaseRpoSsigma factorstranscriptional repression

Identifiers

PMID28830947
PMCPMC5565969
OpenAlexW2747435985

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.