Evidence map›Paper›PMID 28830929›Full record

ArticleThe Journal of biological chemistry2017

Discovery of a widespread prokaryotic 5-oxoprolinase that was hiding in plain sight.

Thomas D Niehaus, Mona Elbadawi-Sidhu, Valérie de Crécy-Lagard, Oliver Fiehn, Andrew D Hanson

Open access · hybridAbstract read
In one paragraph

Article in The Journal of biological chemistry, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.

0numbers the graph read from it
0cells of the map it votes in
40citing papers in PubMed
3.6field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

40 citing papers in PubMed, 78 citations in OpenAlex.

  1. Article
  2. TheApplied and environmental microbiology · 2026
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  3. Growth ofApplied and environmental microbiology · 2026
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  12. Gallium Resistance inApplied microbiology (Basel, Switzerland) · 2025
    Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Challenging a decades-old paradigm: ProB and ProA do not channel the unstable intermediate in proline synthesis after all.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  19. The Transcriptomic Response of Cells of the Thermophilic BacteriumInternational journal of molecular sciences · 2024
    Article
  20. Mutations in thebioRxiv : the preprint server for biology · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Thomas D NiehausFrom the Horticultural Sciences Department, University of Florida, Gainesville, Florida 32611, tomniehaus@ufl.edu.
Mona Elbadawi-Sidhuthe West Coast Metabolomics Center, University of California Davis, Davis, California 95616, and.
Valérie de Crécy-Lagardthe Microbiology and Cell Science Department, University of Florida, Gainesville, Florida 32611.
Oliver Fiehnthe West Coast Metabolomics Center, University of California Davis, Davis, California 95616, and.
Andrew D HansonFrom the Horticultural Sciences Department, University of Florida, Gainesville, Florida 32611, adha@ufl.edu.
University of Florida · USUniversity of California, Davis · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

5-Oxoproline (OP) is well-known as an enzymatic intermediate in the eukaryotic γ-glutamyl cycle, but it is also an unavoidable damage product formed spontaneously from glutamine and other sources. Eukaryotes metabolize OP via an ATP-dependent 5-oxoprolinase; most prokaryotes lack homologs of this enzyme (and the γ-glutamyl cycle) but are predicted to have some way to dispose of OP if its spontaneous formation

Indexed as

Allophanate HydrolaseAmidohydrolasesBacillus subtilisBacterial ProteinsEscherichia coliEscherichia coli ProteinsGene DeletionGene Knockout TechniquesGenomicsMultigene FamilyMutationProtein SubunitsPyrrolidonecarboxylic AcidRecombinant Proteins5-oxoprolinase (ATP-hydrolyzing)Allophanate HydrolaseAmidohydrolasesBacterial ProteinsEscherichia coli ProteinsProtein SubunitsPyrrolidonecarboxylic AcidRecombinant Proteins5-oxoprolinebacterial metabolismglutamateglutaminemetabolismmetabolite damagemetabolite repairmicrobiologypyroglutamate

Identifiers

PMID28830929
PMCPMC5625064
OpenAlexW2748378500

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.