Evidence map›Paper›PMID 28830742›Full record

ArticleSchizophrenia research2018

Emotion discrimination in humans: Its association with HSV-1 infection and its improvement with antiviral treatment.

Triptish Bhatia, Joel Wood, Satish Iyengar, Sreelatha S Narayanan, Ram Pratap Beniwal, Konasale M Prasad, Kehui Chen, Robert H Yolken, Faith Dickerson, Ruben C Gur and 3 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Schizophrenia research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 1 pooled it
1.1field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 1 synthesis or guideline pooled it, 14 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Review
  4. Herpes Simplex Virus Neurovirulence Across the Human Lifespan.The Journal of infectious diseases · 2025
    Review
  5. Review
  6. Article
  7. Article
  8. Review
  9. Article
  10. Review
  11. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 5 institutions in 2 countries.

Triptish BhatiaIndo-US Projects, Dept. of Psychiatry, Centre of Excellence in Mental Health, PGIMER-Dr. Ram Manohar Lohia Hospital, Park Street, New Delhi 110001, India.
Joel WoodDepartment of Psychiatry, WPIC, University of Pittsburgh, Pittsburgh 15213, USA. Electronic address: woodja@upmc.edu.
Satish IyengarDepartment of Psychiatry, WPIC, University of Pittsburgh, Pittsburgh 15213, USA; Department of Statistics, University of Pittsburgh, Pittsburgh 15260, USA. Electronic address: ssi@pitt.edu.
Sreelatha S NarayananGRIP-NIH Project, Dept. of Psychiatry, Centre of Excellence in Mental Health, PGIMER-Dr. Ram Manohar Lohia Hospital, Park Street, New Delhi 110001, India.
Ram Pratap BeniwalDept. of Psychiatry, Centre of Excellence in Mental Health PGIMER-Dr. Ram Manohar Lohia Hospital, Park Street, New Delhi 110001, India.
Konasale M PrasadDepartment of Psychiatry, WPIC, University of Pittsburgh, Pittsburgh 15213, USA. Electronic address: prasadkm@upmc.edu.
Kehui ChenDepartment of Psychiatry, WPIC, University of Pittsburgh, Pittsburgh 15213, USA; Department of Statistics, University of Pittsburgh, Pittsburgh 15260, USA. Electronic address: khchen@pitt.edu.
Robert H YolkenStanley Division of Neurovirology, Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.
Faith DickersonSheppard Pratt IRB, Sheppard Pratt, 6501 North Charles St., Baltimore, MD 21204, USA. Electronic address: fdickerson@sheppardpratt.org.
Ruben C GurPerelman School of Medicine, Department of Psychiatry, University of Pennsylvania, Philadelphia, USA. Electronic address: gur@mail.med.upenn.edu.
Raquel E GurPerelman School of Medicine, Department of Psychiatry, University of Pennsylvania, Philadelphia, USA. Electronic address: raquel@mail.med.upenn.edu.
Smita N DeshpandeDept. of Psychiatry, Centre of Excellence in Mental Health PGIMER-Dr. Ram Manohar Lohia Hospital, Park Street, New Delhi 110001, India.
Vishwajit L NimgaonkarDepartment of Psychiatry, WPIC, University of Pittsburgh, Pittsburgh 15213, USA; Department of Human Genetics, University of Pittsburgh, Pittsburgh 15261, USA. Electronic address: nimga@pitt.edu.
University of Pittsburgh · USAtal Bihari Vajpayee Institute of Medical Sciences and Dr. Ram Manohar Lohia Hospital · INUniversity of Pennsylvania · USJohns Hopkins University · USSheppard and Enoch Pratt Hospital · US

Funding

A Neurobehavioral Family Study of SchizophreniaR01MH063480 · NIMH · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI NIMGAONKAR, VISHWAJIT LAXMIKANT · 2001 to 2018
$6.1M
Psychiatric research infrastructure for intervention and implementation in India – TEAMSD43TW009114 · FIC · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Smita N Deshpande, Mary Elizabeth Hawk · 2014 to 2026
$3.2M
Genetic Susceptibility in SchizophreniaR01MH056242 · NIMH · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI NIMGAONKAR, VISHWAJIT LAXMIKANT · 2002 to 2007
$2.9M
Multi-pronged genetic studies of schizophrenia in an inbred populationR01MH093246 · NIMH · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI MANSOUR, HADER A., NIMGAONKAR, VISHWAJIT LAXMIKANT · 2012 to 2016
$2.6M
Training Program for Psychiatric Genetics in IndiaD43TW006167 · FIC · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI NIMGAONKAR, VISHWAJIT LAXMIKANT · 2002 to 2006
$1.7M
GENETIC SUSCEPTIBILITY IN SCHIZOPHRENIAR10MH056242 · NIMH · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI NIMGAONKAR, VISHWAJIT LAXMIKANT · 1997 to 2001
$1.2M
Tri National Training Program in Psychiatric GeneticsD43TW008302 · FIC · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI MANSOUR, HADER A., NIMGAONKAR, VISHWAJIT LAXMIKANT · 2009 to 2013
$542k
3/5:Family-Based Genome-Wide Methylation Scan in Neurocognition and SchizophreniaRC2MH089859 · NIMH · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI NIMGAONKAR, VISHWAJIT LAXMIKANT · 2009 to 2010
$501k
4/5 Genetics of Transcriptional Endophenotypes in SchizophreniaR01MH093745 · NIMH · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI NIMGAONKAR, VISHWAJIT LAXMIKANT · 2012 to 2014
$224k
3/5: A Genome-Wide Methylation Scan for Epigenetic Contributions to SchizophreniaU01MH085269 · NIMH · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI NIMGAONKAR, VISHWAJIT LAXMIKANT · 2008 to 2012
$187k
FIC NIH HHS D43 TW006167FIC NIH HHS D43 TW008302FIC NIH HHS D43 TW009114NIMH NIH HHS R01 MH056242NIMH NIH HHS R01 MH063480NIMH NIH HHS R01 MH093246NIMH NIH HHS R01 MH093745NIMH NIH HHS R10 MH056242NIMH NIH HHS RC2 MH089859NIMH NIH HHS U01 MH085269
6 · The paper itself

Abstract

backgroundHerpes simplex virus, type 1 (HSV-1) infects over 3.4 billion people, world-wide. Though it can cause encephalitis, in the vast majority it is asymptomatic, with lifelong latent infection in neurons. HSV-1 infected individuals have greater cognitive dysfunction than uninfected individuals, particularly persons with schizophrenia - even without encephalitis. We investigated whether HSV-1 related cognitive dysfunction is progressive or remediable.

methodsIn a prospective naturalistic follow up sample (PNFU), temporal changes in cognitive functions were analyzed in relation to baseline HSV-1 infection in persons with/without schizophrenia (N=226). Independently, in a randomized controlled trial (RCT), HSV-1 infected, clinically stabilized SZ outpatients received Valacyclovir (VAL, an HSV-1 specific antiviral, 1.5G twice daily for 16weeks) or placebo (PLA) added to standard antipsychotic treatment, using a stratified randomization design, following placebo run-in (N=67). In both samples, HSV-1 infection (seropositivity) was estimated using serum IgG antibodies. Clinical evaluations were blinded to HSV-1 or treatment status. Standardized Z scores for accuracy on eight cognitive domains were analyzed for temporal trajectories using generalized linear models (PNFU) and VAL/PLA differences compared with intent to treat analyses (RCT).

resultsPNFU: At baseline, HSV-1 infected participants had significantly lower accuracy scores for Emotion Identification and Discrimination (EMOD), Spatial memory and Spatial ability, regardless of SZ diagnosis (p=0.025, 0.029, 0.046, respectively). They also had significantly steeper temporal worsening for EMOD (p=0.03). RCT: EMOD improved in VAL-treated patients (p=0.048, Cohen's d=0.43).

conclusionsA proportion of age related decline in EMOD is attributable to HSV-1 infection.

Indexed as

AcyclovirAdolescentAdultAntipsychotic AgentsAntiviral AgentsCognition DisordersEmotionsFemaleFollow-Up StudiesHerpes SimplexHumansMaleMiddle AgedNeuropsychological TestsRandomized Controlled Trials as TopicSeverity of Illness IndexAcyclovirAntipsychotic AgentsAntiviral AgentsValacyclovirValineCognitionEmotionHerpes virusHSV-1MemorySchizophreniaValacyclovir

Identifiers

PMID28830742
PMCPMC5818324
OpenAlexW2746697491

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.