ArticleGenome biology2017
Altered chromatin compaction and histone methylation drive non-additive gene expression in an interspecific Arabidopsis hybrid.
Article in Genome biology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 66 papers.
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66 citing papers in PubMed, 118 citations in OpenAlex.
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- Hybridization and gene expression: Beyond differentially expressed genes.Molecular ecology · 2025Review
- Reactivation of the tRNASer/tRNATyr gene cluster in Arabidopsis thaliana root tips.The Plant cell · 2025Article
- Epigenetics in the modern era of crop improvements.Science China. Life sciences · 2025Review
- Empowering plant epigenetics to breed resilience of crops: From nucleolar dominance to transgenerational epigenetic inheritance.The plant genome · 2025Review
- Centromere-size reduction and chromatin state dynamics following intergenomic hybridization in cotton.PLoS genetics · 2025Article
- A telomere-to-telomere chromosome-scale genome assembly of glass catfish (Kryptopterus vitreolus).Scientific data · 2025Article
- Whole-Genome DNA Methylation Analysis of Inoculation withJournal of fungi (Basel, Switzerland) · 2025Article
- Different complex regulatory phenotypes underlie hybrid male sterility in divergent rodent crosses.Genetics · 2025Article
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- Different complex regulatory phenotypes underlie hybrid male sterility in divergent rodent crosses.bioRxiv : the preprint server for biology · 2024Article
- Transgenerational epigenetic inheritance during plant evolution and breeding.Trends in plant science · 2024Review
- Chromosome-level genome assembly of the glass catfish (Zoological research · 2024Article
- An atlas of the tomato epigenome reveals that KRYPTONITE shapes TAD-like boundaries through the control of H3K9ac distribution.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Genome evolution of the ancient hexaploidProceedings of the National Academy of Sciences of the United States of America · 2024Article
- 3D genome structural variations play important roles in regulating seed oil content of Brassica napus.Plant communications · 2024Article
- The Genomic Shock Hypothesis: Genetic and Epigenetic Alterations of Transposable Elements after Interspecific Hybridization in Plants.Epigenomes · 2023Review
6 more citing papers are in PubMed but not listed here.
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7 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe merging of two diverged genomes can result in hybrid offspring that phenotypically differ greatly from both parents. In plants, interspecific hybridization plays important roles in evolution and speciation. In addition, many agricultural and horticultural species are derived from interspecific hybridization. However, the detailed mechanisms responsible for non-additive phenotypic novelty in hybrids remain elusive.
resultsIn an interspecific hybrid between Arabidopsis thaliana and A. lyrata, the vast majority of genes that become upregulated or downregulated relative to the parents originate from A. thaliana. Among all differentially expressed A. thaliana genes, the majority is downregulated in the hybrid. To understand why parental origin affects gene expression in this system, we compare chromatin packing patterns and epigenomic landscapes in the hybrid and parents. We find that the chromatin of A. thaliana, but not that of A. lyrata, becomes more compact in the hybrid. Parental patterns of DNA methylation and H3K27me3 deposition are mostly unaltered in the hybrid, with the exception of higher CHH DNA methylation in transposon-rich regions. However, A. thaliana genes enriched for the H3K27me3 mark are particularly likely to differ in expression between the hybrid and parent.
conclusionsIt has long been suspected that genome-scale properties cause the differential responses of genes from one or the other parent to hybridization. Our work links global chromatin compactness and H3K27me3 histone modification to global differences in gene expression in an interspecific Arabidopsis hybrid.
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