ArticleParticle and fibre toxicology2017
Prenatal tobacco smoke exposure predisposes offspring mice to exacerbated allergic airway inflammation associated with altered innate effector function.
Article in Particle and fibre toxicology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 26 citations in OpenAlex.
- Trial
- The evolution of lipid nanoparticles: Paving the way for next-generation nucleic acid medicines.Asian journal of pharmaceutical sciences · 2026Review
- Review
- Risk factor analysis and nomogram for predicting poor symptom control in smoking asthmatics.BMC pulmonary medicine · 2024Article
- A review of common influencing factors and possible mechanisms associated with allergic diseases complicating tic disorders in children.Frontiers in pediatrics · 2024Review
- Are Babies Born Preterm High-Risk Asthma Candidates?Journal of clinical medicine · 2023Review
- Preterm Birth, Developmental Smoke/Nicotine Exposure, and Life-Long Pulmonary Sequelae.Children (Basel, Switzerland) · 2023Review
- Prenatal and Postnatal Cigarette Smoke Exposure Is Associated With Increased Risk of Exacerbated Allergic Airway Immune Responses: A Preclinical Mouse Model.Frontiers in immunology · 2021Article
- Prenatal and early life exposure to particulate matter, environmental tobacco smoke and respiratory symptoms in Mexican children.Environmental research · 2021Article
- Prenatal smoke exposure induces persistentEpigenetics · 2020Article
- Early life exposures shape the CD4Scientific reports · 2019Article
- Environmental exposures and mechanisms in allergy and asthma development.The Journal of clinical investigation · 2019Review
- Early life inhalation exposure to mine tailings dust affects lung development.Toxicology and applied pharmacology · 2019Article
- Treatment of Allergic Rhinitis as a Strategy for Preventing Asthma.Current allergy and asthma reports · 2018Review
- Environmental cues received during development shape dendritic cell responses later in life.PloS one · 2018Article
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundEpidemiological studies suggest that prenatal and early life environmental exposures have adverse effects on pulmonary function and are important contributors in the development of childhood asthma and allergic disease. The mechanism by which environmental tobacco smoke (ETS) exposure in utero promotes the development of allergic asthma remains unclear. In this study, we investigated the immunological consequences of prenatal exposure to ETS in order to understand events responsible for the development or exacerbation of allergic asthma.
methodsPregnant C57BL/6 mice were exposed to either ETS or filtered air throughout gestation and the effect on pulmonary inflammation in the offspring were examined and compared. Specifically, the effects on eosinophilic inflammation, airway hyperreactivity, goblet cell hyperplasia, properties of pulmonary natural killer (NK) cells and type 2 cytokines elicited in response to inhaled house dust mite (HDM) allergen were investigated in the progeny.
resultsExposure to ETS prenatally significantly exacerbated HDM-induced airway eosinophilic inflammation, hyperreactivity, mucus secretion, cysteinyl leukotriene biosynthesis and type 2 cytokine production in the offspring. Consistently, lung mononuclear cells from ETS-exposed offspring secreted higher levels of IL-13 when stimulated in vitro with anti-αβ TCR antibody or HDM allergen. Moreover, offspring from ETS-exposed dams exhibited a higher frequency of CD11b
conclusionOur results reveal that prenatal exposure to ETS predisposes offspring to an exacerbated allergic airway inflammation that is associated with a reduction in pulmonary NK cell function, suggesting that NK cells play a key role in controlling asthma severity.
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