Evidence map›Paper›PMID 28830483›Full record

ArticleBMC women's health2017

Results of a pilot study in the U.S. and Vietnam to assess the utility and acceptability of a multi-level pregnancy test (MLPT) for home monitoring of hCG trends after assisted reproduction.

Tara Shochet, Ioanna A Comstock, Nguyen Thi Nhu Ngoc, Lynn M Westphal, Wendy R Sheldon, Ly Thai Loc, Jennifer Blum, Beverly Winikoff, Paul D Blumenthal

2 registry-linked trialsAbstract read
In one paragraph

Article in BMC women's health, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01846403 nacompletednot on this map

Feasibility and Acceptability of Using the Semi-quantitative Pregnancy Test to Replace Sequential Serum hCG Testing in an Assisted Fertility Setting

TypeinterventionalSponsorGynuity Health ProjectsRan2013 to 2013Enrolled50ConditionsEmbryo TransferArmsSemi-quantitative urine pregnancy test
NCT01919502 nacompletednot on this map

Feasibility and Acceptability of Using a Semi-quantitative Pregnancy Test to Monitor hCG Levels After Assisted Fertility Treatment

TypeinterventionalSponsorGynuity Health ProjectsRan2013 to 2014Enrolled51ConditionsEmbryo Transfer, Intrauterine Insemination (IUI)ArmsSemi-quantitative urine pregnancy test
3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Tara ShochetGynuity Health Projects, 15 East 26th Street, Suite 801, New York, NY, 10010, USA. tshochet@gynuity.org.ORCID 0000-0003-3651-5957
Ioanna A ComstockGeorge Washington University, 2150 Pennsylvania Ave NW, Washington, DC, 20036, USA.
Nguyen Thi Nhu NgocCenter for Research and Consultancy in Reproductive Health, 16D, Luy Ban Bich, Tan Thoi Hoa, Tan Phu District, Ho Chi Minh City, 70000, Vietnam.
Lynn M WestphalReproductive Endocrinology, Stanford University, 900 Welch Road, Suite 20, Palo Alto, CA, 94304, USA.
Wendy R SheldonGynuity Health Projects, 15 East 26th Street, Suite 801, New York, NY, 10010, USA.
Ly Thai LocHung Vuong Hospital, 128 Hong Bang Street, Ward 12, District 5, Ho Chi Minh City, Vietnam.
Jennifer BlumGynuity Health Projects, 15 East 26th Street, Suite 801, New York, NY, 10010, USA.
Beverly WinikoffGynuity Health Projects, 15 East 26th Street, Suite 801, New York, NY, 10010, USA.
Paul D BlumenthalStanford University Medical Center, 300 Pasteur Drive, Stanford, CA, 94304, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundTo evaluate the utility and acceptability of using multi-level pregnancy tests (MLPTs) at home to monitor hCG trends following assisted reproductive technology (ART).

methodsOne hundred and four women presenting for ART at either Stanford Medicine Fertility and Reproductive Health Clinic (Stanford, CA) or Hung Vuong Hospital (Ho Chi Minh City, Vietnam) participated in this pilot study. Women were asked to perform the MLPT at home, primarily on days when they were also scheduled to receive standard clinic-based serum hCG testing. These tests were administered up to 6 times over the 6-week period following embryo transfer or intrauterine insemination (IUI). Concordance of serial hCG readings for each time point was assessed by comparing trends in urine MLPT results with trends in serum hCG. Stable or increasing hCG level was interpreted as an indication of a progressing pregnancy, while a declining hCG was interpreted as a lack of established or progressing pregnancy. At study end, all participants were asked about the acceptability and convenience of using the MLPT at home for monitoring hCG trends following ART.

resultsData from both urine and serum testing are available for 156 of 179 clinic visits (87.2%). There was high concordance of serial trend results between the two types of tests: among the 156 sets of serum and urine hCG data points, 150 (96.2%) showed a matching trend in hCG pattern and 6 (3.8%) resulted in a discordant trend. Seventy-three percent of women reported being satisfied or very satisfied with using the MLPTs at home. Almost all (96.6%) said that the MLPT was easy or very easy to use.

conclusionThe MLPT offers women and health care providers a client-friendly diagnostic tool to detect very early pregnancy and monitor its progress.

trial registrationThis study was registered on clinicaltrials.gov as NCT01846403 (May 1, 2013), and NCT01919502 (August 5, 2013).

Indexed as

AdultChorionic GonadotropinEmbryo TransferFemaleHumansPatient Acceptance of Health CarePilot ProjectsPregnancyPregnancy TestsReproductionReproductive Techniques, AssistedUnited StatesVietnamChorionic GonadotropinAssisted fertilityhCGMulti-level pregnancy testSemi-quantitative pregnancy test

Identifiers

PMID28830483
PMCPMC5567887

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.