ArticleBMC musculoskeletal disorders2017
Total knee Arthroplasty: risk factors for allogeneic blood transfusions in the South Asian population.
Article in BMC musculoskeletal disorders, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 2 of them syntheses that pooled it.
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Who cites it
10 citing papers in PubMed, 2 syntheses or guidelines pooled it, 28 citations in OpenAlex.
- Risk factors for perioperative blood transfusion in total hip arthroplasty: a meta-analysis.BMC musculoskeletal disorders · 2025Pooled it
- Effectiveness and safety of the use of antifibrinolytic agents in total-knee arthroplasty: A meta-analysis.Medicine · 2020Pooled it
- Does the accelerometer-based navigation system reduce blood loss and transfusion in one-stage sequential bilateral total knee arthroplasty? A randomized double-blind controlled trial.BMC musculoskeletal disorders · 2023Trial
- Simultaneous bilateral total knee arthroplasty lowers reoperation and cost at the expense of higher complications and mortality: a meta-analysis and systematic review.Knee surgery & related research · 2025Review
- Prevalence of Blood Transfusion and Factors Influencing Blood Loss Following Primary Total Knee Replacement Surgery.Malaysian orthopaedic journal · 2025Article
- Factors associated with increased risk of postoperative blood transfusion in patients undergoing total hip arthroplasty at an Irish University Hospital.Irish journal of medical science · 2024Article
- Article
- Predict Postoperative Anemia of Patients: Nomogram Construction and Validation.Frontiers in surgery · 2022Article
- Efficacy and Safety of Intravenous Ferric Carboxymaltose in Patients with Postoperative Anemia Following Same-Day Bilateral Total Knee Arthroplasty: A Randomized Controlled Trial.Journal of clinical medicine · 2021Article
- Development and validation of a nomogram to predict perioperative blood transfusion in patients undergoing total knee arthroplasty.BMC musculoskeletal disorders · 2020Article
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundTotal knee arthroplasty (TKA) is the recommended treatment for end-stage knee osteoarthritis. Considering the various risks associated with intra and postoperative blood transfusions, better understanding is required with respect to the risk factors contributing to a greater possibility of blood transfusion during or after surgery. Although literature highlights several such factors, our study is among the first to identify these risk factors in the South Asian population which differs from other populations in several ways.
methodsThe study consists of a review of 658 patients undergoing TKA from 2005 to 2015. Data was obtained from patient medical records and was analysed using logistic regression analysis. The relationship between each predictor and the outcome variable was calculated as an Odds ratio (OR), the threshold of significance for which was p = 0.25 and p = 0.05 for univariate and multivariable analysis respectively.
resultsThe mean age of the patient population was 63 years (78% female), 25% of whom received one or more blood transfusions. Multivariable analysis revealed 5 significant independent predictors for increased risk of blood transfusions including bilateral knee surgery (OR:5.51), preoperative anemia (OR:4.15), higher ASA (American Society of Anaesthesiologists) status (3-4) (OR:1.92), female sex (OR:3.44) and BMI (Body mass index) ≤30 (OR:1.79) while increasing co-morbidities and age (>60) were found to be insignificant.
conclusionsThe factors identified for the South Asian population are largely similar to those for other populations. Identification of high risk patients will permit the application of an international multipronged approach which not only targets the modifiable risk factors but also the decision making process and blood management protocols in order to minimize the transfusion associated risks for a patient undergoing a TKA.
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