ArticleBMC medical genetics2017
Allelic variants in vitamin D receptor gene are associated with adiposity measures in the central-European population.
Article in BMC medical genetics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
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Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it, 27 citations in OpenAlex.
- Vitamin D Receptor Polymorphisms Associated with Susceptibility to Obesity: A Meta-Analysis.Medical science monitor : international medical journal of experimental and clinical research · 2019Pooled it
- Vitamin D receptor gene polymorphisms affecting changes in visceral fat, waist circumference and lipid profile in breast cancer survivors supplemented with vitamin D3.Lipids in health and disease · 2019Trial
- Gc inhibition preserves insulin sensitivity and reduces body weight without loss of muscle mass.JCI insight · 2025Article
- A case of familial partial lipodystrophy type 2 masquerading as Cushing syndrome: Explaining an atypical phenotype by whole-exome sequencing.Archives of endocrinology and metabolism · 2025Article
- Article
- Exploring the Interplay of Genetics and Nutrition in the Rising Epidemic of Obesity and Metabolic Diseases.Nutrients · 2024Review
- Genetic Variability in Vitamin D Receptor and Migraine Susceptibility: A Southeastern European Case-Control Study.Neurology international · 2023Article
- Association of Vitamin D Receptor Gene Polymorphisms with Cardiometabolic Phenotypes in Hispanics: A Life Course Approach.Nutrients · 2023Article
- Review
- VDR Gene Polymorphisms and Cluster Headache Susceptibility: Case-Control Study in a Southeastern European Caucasian Population.Journal of molecular neuroscience : MN · 2022Article
- Vitamin D Supplementation and Genetic Polymorphisms Impact on Weight Loss Diet Outcomes in Caucasians: A Randomized Double-Blind Placebo-Controlled Clinical Study.Frontiers in medicine · 2022Article
- Narrative role of vitamin D receptor with osteoporosis and obesity in a sample of Egyptian females: a pilot study.Journal, genetic engineering & biotechnology · 2021Article
- Vitamin D pathway-related gene polymorphisms and their association with metabolic diseases: A literature review.Journal of diabetes and metabolic disorders · 2020Review
- Genetic variants of VDR and CYP2R1 affect BMI independently of serum vitamin D concentrations.BMC medical genetics · 2020Article
- The relationship between hypertriglyceridemic-waist phenotype and vitamin D status in type 2 diabetes.Diabetes, metabolic syndrome and obesity : targets and therapy · 2019Article
- Apa-I polymorphism in VDR gene is related to metabolic syndrome in polycystic ovary syndrome: a cross-sectional study.Reproductive biology and endocrinology : RB&E · 2018Article
- Vitamin D status and functional parameters: A cross-sectional study in an older population.PloS one · 2018Article
Corrections and comments
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Authors and funding
8 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThere is an increasing body of evidence suggesting that vitamin D is involved in ethiopathogenesis of obesity and therefore the aim of the study was to investigate whether 5 selected SNPs in VDR (vitamin D receptor) gene are associated also with anthropometry in the obese and non-obese Central-European population.
methodsA total of 882 Central European Caucasian individuals of Czech origin were recruited (n = 882, 232 M/650 F) and weight, height, BMI, lean body mass, fat mass, body fat, waist and hip circumference, waist-hip ratio (WHR) and skinfold thickness were measured. Univariate and multivariate models were constructed in order to investigate the relationship between anthropometry and VDR polymorphisms.
resultsIn the univariate modeling, the CC genotype of FokI SNP was associated with reduced waist circumference (β = -3.48; 95%CI:-7.11;0.15; p = 0.060), sum of skin fold thickness (β = -6.53, 95% CI: -12.96;-0.11; p = 0.046) as well as total % of body fat (β = -3.14, 95% CI: -5.18;-1.09; p = 0.003) compared to TT genotype. The AC genotype of ApaI SNP was associated with reduced waist circumference compared to AA genotype (β = -4.37, 95% CI: -7.54;-1.20; p = 0.007). GG genotype of EcoRV SNP was associated with reduced sum of skin fold thickness compared to AA genotype (β = -7.77, 95% CI: -14.34;-1.21; p = 0.020). In the multivariate modelling, multiple significant associations of VDR with investigated traits were observed, too.
conclusionOur study suggests that genetic variability in the VDR region may be an important factor influencing anthropometric characteristics associated with obesity.
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