Observational studyTherapeutic advances in cardiovascular disease2017
Left atrial volume index in patients with heart failure and severely impaired left ventricular systolic function: the role of established echocardiographic parameters, circulating cystatin C and galectin-3.
Observational study in Therapeutic advances in cardiovascular disease, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 27 citations in OpenAlex.
- Prognostic Value of Cystatin C Across Ejection Fraction Spectrum in Heart Failure With Normal to Mild Renal Dysfunction Original Investigation.Clinical cardiology · 2026Article
- Complementary insights into novel biomarkers for acute myocardial infarction: reinforcing the role of a multimarker strategy.Journal of thoracic disease · 2025Article
- Quantitative assessment of changes in left ventricular myocardial work and energy loss in HER2-positive breast cancer patients undergoing combination therapy with chemotherapy and targeted treatment using pressure-strain loop and vector flow mapping.Quantitative imaging in medicine and surgery · 2025Article
- Evaluating the Prognostic Significance of Cystatin C Level Variations Pre- and Post-Radiofrequency Catheter Ablation in the Recurrence of Persistent Atrial Fibrillation.Annals of noninvasive electrocardiology : the official journal of the International Society for Holter and Noninvasive Electrocardiology, Inc · 2024Article
- Correlation of serum homocysteine and cystatin C levels with prognosis in heart failure with preserved ejection fraction patients.BMC cardiovascular disorders · 2024Article
- [Cirrhotic cardiomyopathy – Clinically fact or academic curiosity? Review. Part 2: ECG, functional tests, images, biomarkers, screening for coronary heart disease and differentianting diagnosis]Revista de la Facultad de Ciencias Medicas (Cordoba, Argentina) · 2024Review
- [Cirrhotic cardiomyopathy – Clinically fact or academic curiosity? Review: Part 1: definition, epidemiology, pathology and clinical manifestations]Revista de la Facultad de Ciencias Medicas (Cordoba, Argentina) · 2024Article
- Assessment and management of heart failure in patients with chronic kidney disease.Heart failure reviews · 2024Review
- Interaction between secondary mitral regurgitation and left atrial function and their prognostic implications after cardiac resynchronization therapy.European heart journal. Cardiovascular Imaging · 2023Article
- Lipocalin-2, S100A8/A9, and cystatin C: Potential predictive biomarkers of cardiovascular complications in COVID-19.Experimental biology and medicine (Maywood, N.J.) · 2022Article
- Pathogenic Mechanisms Underlying Cirrhotic Cardiomyopathy.Frontiers in network physiology · 2022Review
- Biomarkers in Heart Failure with Preserved Ejection Fraction.Cardiac failure review · 2022Review
- What's New in Cirrhotic Cardiomyopathy?-Review Article.Journal of personalized medicine · 2021Review
- Cirrhotic Cardiomyopathy.Current gastroenterology reports · 2020Review
- The Biomarkers for Acute Myocardial Infarction and Heart Failure.BioMed research international · 2020Review
- Intermediate filaments in cardiomyopathy.Biophysical reviews · 2018Review
- Cystatin C and galectin-3 as therapeutic targets in heart failure.Therapeutic advances in cardiovascular disease · 2018Article
- Letter to the Editor regarding the article 'Left atrial volume index in patients with heart failure and severely impaired left ventricular systolic function: the role of established echocardiographic parameters, circulating cystatin C and galectin-3' by Zivlas et al. (2017).Therapeutic advances in cardiovascular disease · 2018Article
- Atrial remodelling in heart failure: recent developments and relevance for heart failure with preserved ejection fraction.ESC heart failure · 2018Article
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Authors and funding
11 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Backround: Left atrial (LA) enlargement plays an important role in the development of heart failure (HF) and is a robust prognostic factor. Fibrotic processes have also been advocated to evoke HF through finite signalling proteins.
methodsWe examined the association of two such proteins, cystatin C (CysC) and galectin-3 (Gal-3), and other clinical, echocardiographic and biochemical parameters with LA volume index (LAVi) in patients with HF with severely impaired left ventricular ejection fraction (LVEF). Severe renal, liver, autoimmune disease and cancer were exclusion criteria.
resultsA total of 40 patients with HF (31 men, age 66.6 ± 1.7) with LVEF = 25.4 ± 0.9% were divided into two groups according to the mean LAVi (51.03 ± 2.9 ml/m
conclusionsApart from known determinants of LAVi, circulating CysC and Gal-3 were associated with greater LA dilatation in patients with HF with reduced LVEF. Interestingly, the correlation between these two fibrotic proteins was positive.
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