Evidence map›Paper›PMID 28830202›Full record

ArticleThe British journal of radiology2017

Radiological distribution of brain metastases and its implication for the hippocampus avoidance in whole brain radiotherapy approach.

Yi-Min Han, Gang Cai, Wei-Min Chai, Cheng Xu, Lu Cao, Dan Ou, Jia-Yi Chen, Youlia M Kirova

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PubMed Full text at PMC Publisher
In one paragraph

Article in The British journal of radiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 3 pooled it
0.8field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 3 syntheses or guidelines pooled it, 18 citations in OpenAlex.

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  11. New developments in brain metastases.Therapeutic advances in neurological disorders · 2018
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Yi-Min Han1 Department of Radiation Oncology, Ruijin Hospital, Shanghai Jiao Tong University, Shanghai, China.
Gang Cai1 Department of Radiation Oncology, Ruijin Hospital, Shanghai Jiao Tong University, Shanghai, China.
Wei-Min Chai2 Department of Radiology, RuiJin Hospital, Shanghai Jiao Tong University, Shanghai, China.
Cheng Xu1 Department of Radiation Oncology, Ruijin Hospital, Shanghai Jiao Tong University, Shanghai, China.
Lu Cao1 Department of Radiation Oncology, Ruijin Hospital, Shanghai Jiao Tong University, Shanghai, China.
Dan Ou1 Department of Radiation Oncology, Ruijin Hospital, Shanghai Jiao Tong University, Shanghai, China.
Jia-Yi Chen1 Department of Radiation Oncology, Ruijin Hospital, Shanghai Jiao Tong University, Shanghai, China.
Youlia M Kirova3 Department of Radiation Oncology, Institut Curie, Paris, France.
Shanghai Jiao Tong University · CNRuijin Hospital · CNInstitut Curie · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveHippocampus avoidance in whole brain radiotherapy (HA-WBRT) offers the feasibility of less-impaired cognitive function than conventional WBRT. The study aims to assess the radiological distribution of brain metastases (BMs) with relation to the hippocampus and peri-hippocampus region as defined by the RTOG 0933 for better understanding of margin definition in HA-WBRT treatment planning.

methodsConsecutive patients with diagnosis of BM from enhanced MRI between March 2011 and July 2016 were analysed. The pre-treatment T

resultsA total of 226 patients with 1080 visible metastatic sites were reviewed. The origin of the primary tumors was in 72.6% lung (n = 164), in 45 cases (19.9%) breast cancer and in 7.5% other malignancies (n = 17). There were 758 (70.2%) lesions situated beyond the tentorium. The median size of single lesion was 13.9 ± 14.7 mm. Impossible, it seems that more of the patients are with only one lesion, to verify. The hippocampus involvement was found in 3.1% (n = 7, 95% CI 0.01-0.05) within 5 mm, 5.7% (n = 13, 95% CI 0.03-0.09) within 10mm and 8.4% (n = 19, 95% CI 0.05-0.12) within 20 mm. In multivariate analysis, the number 6 BM or higher was found to be an independent risk factor for hippocampal involvement (HI) (OR: 5.2, 5.38 and 3.84 in 5, 10 and 20 mm).

conclusionThis radiological study found that the incidence of hippocampus involvement is low in patients with BM. HA-WBRT can be delivered under the context of complete radiological diagnosis after careful delineation, proper margin definition and individual planning optimization. Advances in knowledge: The incidence of HI in patients with initial diagnosis of BM from solid tumours impacts the radiotherapeutic decision. Our radiological data analysed the incidence of HI not only to the conventional 5 mm margin definition, but also expanded to wider margins as 10 and 20 mm from hippocampus, which will help the treatment planning optimization with different technique.

Indexed as

AdultAgedAged, 80 and overAnalysis of VarianceBrain NeoplasmsBreast NeoplasmsCranial IrradiationFemaleHippocampusHumansLung NeoplasmsMagnetic Resonance ImagingMaleMiddle AgedOrgan Sparing TreatmentsTumor Burden

Identifiers

PMID28830202
PMCPMC5963386
OpenAlexW2745660196

What OpenQuestion holds

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Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.