ReviewThe British journal of radiology2017
Enhanced radiation dose and DNA damage associated with iodinated contrast media in diagnostic X-ray imaging.
Review in The British journal of radiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
9 citing papers in PubMed, 24 citations in OpenAlex.
- Feasibility of reducing radiation dose and contrast dose while improving image quality in dual-energy CT pulmonary angiography : Use of low-energy virtual monochromatic images with deep learning image reconstruction algorithm.Radiologie (Heidelberg, Germany) · 2026Article
- Contrast induced nephropathy in women with infertility undergoing hysterosalpingography.Reproductive biology and endocrinology : RB&E · 2024Article
- A patient- and acquisition-tailored injection approach for improving consistency of CT enhancement towards a target CT value in coronary CT angiography.Journal of applied clinical medical physics · 2023Article
- What level of D-dimers can safely exclude pulmonary embolism in COVID-19 patients presenting to the emergency department?European radiology · 2022Article
- Potential increase in radiation-induced DNA double-strand breaks with higher doses of iodine contrast during coronary CT angiography.Medical physics · 2021Article
- The presence of contrast agent increases organ radiation dose in contrast-enhanced CT.European radiology · 2021Article
- DNA Damage in Blood Leukocytes of Prostate Cancer Patients Undergoing PET/CT Examinations with [Cancers · 2020Article
- The molecular mechanism of contrast-induced nephropathy (CIN) and its link to in vitro studies on iodinated contrast media (CM).BioMedicine · 2018Article
- High Concentration of Iopromide Induces Apoptosis and Autophagy in Human Embryonic Kidney CellsIn vivo (Athens, Greece)Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A review was undertaken of studies reporting increased DNA damage in circulating blood cells and increased organ doses, for X-ray exposures enhanced by iodinated contrast media (ICM), compared to unenhanced imaging. This effect may be due to ICM molecules acting as a source of secondary radiation (Auger/photoelectrons, fluorescence X-rays) following absorption of primary X-ray photons. It is unclear if the reported increase in DNA damage to blood cells necessarily implies an increased risk of developing cancer. Upon ICM-enhancement, the attenuation properties of blood differ substantially from surrounding tissues. Increased energy deposition is likely to occur within very close proximity to ICM molecules (within a few tens of micrometres). Consequently, in many situations, damage and dose enhancement may be restricted to the blood and vessel wall only. Increased cancer risks may be possible, in cases where ICM molecules are given sufficient time to reach the capillary network and interstitial fluid at the time of exposure. In all situations, the extrapolation of blood cell damage to other tissues requires caution where contrast media are involved. Future research is needed to determine the impact of ICM on dose to cells outside the blood itself and vessel walls, and to determine the concentration of ICM in blood vessels and interstitial fluid at the time of exposure.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.