SynthesisEuropean journal of cancer (Oxford, England : 1990)2017
Pro-inflammatory fatty acid profile and colorectal cancer risk: A Mendelian randomisation analysis.
Open access · hybridAbstract readMeta-Analysis
In one paragraph
Synthesis in European journal of cancer (Oxford, England : 1990), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers, 2 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
51citing papers in PubMed, 2 pooled it
4.2field-weighted citation impact, top 4% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
51 citing papers in PubMed, 2 syntheses or guidelines pooled it, 109 citations in OpenAlex.
- Comprehensive Investigation on Associations between Dietary Intake and Blood Levels of Fatty Acids and Colorectal Cancer Risk.Nutrients · 2023Pooled it
- Systematic review of Mendelian randomization studies on risk of cancer.BMC medicine · 2022Pooled it
- Plasma Metabolomics Analysis of Aspirin Treatment and Risk of Colorectal Adenomas.Cancer prevention research (Philadelphia, Pa.) · 2022Trial
- Metabolomics Analysis of Aspirin's Effects in Human Colon Tissue and Associations with Adenoma Risk.Cancer prevention research (Philadelphia, Pa.) · 2020Trial
- Mendelian randomisation analysis to discover plasma metabolites mediating the effect of obesity on cancer risk.British journal of cancer · 2025Article
- Genetically predicted inflammatory protein mediate the association between lipidome and colon cancer.Discover oncology · 2025Article
- Blood metabolic biomarkers and colorectal cancer risk: results from large prospective cohort and Mendelian randomisation analyses.British journal of cancer · 2025Article
- Protective impact of circulating ω-3 PUFAs on sepsis susceptibility throughFrontiers in medicine · 2025Article
- Unveiling fatty acid subtypes: immunometabolic interplay and therapeutic opportunities in gastric cancer.Frontiers in oncology · 2025Article
- Lipidomics Profiling Reveals Differential Alterations after FAS Inhibition in 3D Colon Cancer Cell Culture Models.Journal of proteome research · 2024Article
- Role of dietary nutrients and metabolism in colorectal cancer.Asia Pacific journal of clinical nutrition · 2024Review
- Mendelian randomisation analysis for intestinal disease: achievement and future.eGastroenterology · 2024Review
- Phenome-wide Mendelian randomisation analysis of 378,142 cases reveals risk factors for eight common cancers.Nature communications · 2024Article
- Understanding the Role of Polyunsaturated Fatty Acids in the Development and Prevention of Cancer.Cancer treatment and research · 2024Review
- Identifying metabolic features of colorectal cancer liability using Mendelian randomization.eLife · 2023Article
- Identifying metabolic features of colorectal cancer liability using Mendelian randomization.medRxiv : the preprint server for health sciences · 2023Article
- The effect of FTO gene rs9939609 polymorphism on the association between colorectal cancer and different types of dietary fat intake: a case-control study.Journal of physiological anthropology · 2023Article
- Unveiling the MUFA-Cancer Connection: Insights from Endogenous and Exogenous Perspectives.International journal of molecular sciences · 2023Review
- Serum Saturated Fatty Acids including Very Long-Chain Saturated Fatty Acids and Colorectal Cancer Risk among Chinese Population.Nutrients · 2023Article
- Risk factors for eight common cancers revealed from a phenome-wide Mendelian randomisation analysis of 378,142 cases and 485,715 controls.medRxiv : the preprint server for health sciences · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
54 authors at 20 institutions in 6 countries.
Sebastian May-WilsonDivision of Genetics and Epidemiology, The Institute of Cancer Research, London, SW7 3RP, UK.
Amit SudDivision of Genetics and Epidemiology, The Institute of Cancer Research, London, SW7 3RP, UK.
Philip J LawDivision of Genetics and Epidemiology, The Institute of Cancer Research, London, SW7 3RP, UK.
Kimmo PalinGenome-Scale Biology Research Program, Research Programs Unit, University of Helsinki, Helsinki, 00014, Finland; Department of Medical and Clinical Genetics, Medicum, University of Helsinki, Helsinki, 00014, Finland.
Sari TuupanenGenome-Scale Biology Research Program, Research Programs Unit, University of Helsinki, Helsinki, 00014, Finland; Department of Medical and Clinical Genetics, Medicum, University of Helsinki, Helsinki, 00014, Finland.
Alexandra GylfeGenome-Scale Biology Research Program, Research Programs Unit, University of Helsinki, Helsinki, 00014, Finland; Department of Medical and Clinical Genetics, Medicum, University of Helsinki, Helsinki, 00014, Finland.
Ulrika A HänninenGenome-Scale Biology Research Program, Research Programs Unit, University of Helsinki, Helsinki, 00014, Finland; Department of Medical and Clinical Genetics, Medicum, University of Helsinki, Helsinki, 00014, Finland.
Tatiana CajusoGenome-Scale Biology Research Program, Research Programs Unit, University of Helsinki, Helsinki, 00014, Finland; Department of Medical and Clinical Genetics, Medicum, University of Helsinki, Helsinki, 00014, Finland.
Tomas TanskanenGenome-Scale Biology Research Program, Research Programs Unit, University of Helsinki, Helsinki, 00014, Finland; Department of Medical and Clinical Genetics, Medicum, University of Helsinki, Helsinki, 00014, Finland.
Johanna KondelinGenome-Scale Biology Research Program, Research Programs Unit, University of Helsinki, Helsinki, 00014, Finland; Department of Medical and Clinical Genetics, Medicum, University of Helsinki, Helsinki, 00014, Finland.
Eevi KaasinenGenome-Scale Biology Research Program, Research Programs Unit, University of Helsinki, Helsinki, 00014, Finland; Department of Medical and Clinical Genetics, Medicum, University of Helsinki, Helsinki, 00014, Finland.
Antti-Pekka SarinInstitute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, 00014, Finland.
Johan G ErikssonNational Institute for Health and Welfare, Helsinki, 00271, Finland; Folkhälsan Research Centre, Helsinki, 00250, Finland; Unit of General Practice and Primary Health Care, University of Helsinki and Helsinki University Hospital, Helsinki, 00014, Finland.
Harri RissanenNational Institute for Health and Welfare, Helsinki, 00271, Finland.
Paul KnektNational Institute for Health and Welfare, Helsinki, 00271, Finland.
Eero PukkalaFinnish Cancer Registry, Institute for Statistical and Epidemiological Cancer Research, Helsinki, 00130, Finland; School of Health Sciences, University of Tampere, Tampere, 33014, Finland.
Pekka JousilahtiNational Institute for Health and Welfare, Helsinki, 00271, Finland.
Veikko SalomaaNational Institute for Health and Welfare, Helsinki, 00271, Finland.
Samuli RipattiInstitute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, 00014, Finland; Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, CB10 1SA, UK; Department of Public Health, University of Helsinki, Helsinki, 00014, Finland.
Aarno PalotieInstitute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, 00014, Finland; Analytic and Translational Genetics Unit, Department of Medicine, Massachusetts General Hospital, Boston, MA, 02114, USA; Program in Medical and Population Genetics, The Broad Institute of MIT and Harvard, Cambridge, MA, 02142, USA; Department of Neurology, Massachusetts General Hospital, Boston, MA, 02114, USA.
Laura Renkonen-SinisaloAbdominal Center, Department of Surgery, Helsinki University Hospital, Helsinki, 00029, Finland.
Anna LepistöAbdominal Center, Department of Surgery, Helsinki University Hospital, Helsinki, 00029, Finland.
Jan BöhmDepartment of Pathology, Central Finland Central Hospital, Jyväskylä, 40620, Finland.
Jukka-Pekka MecklinDepartment of Surgery, Jyväskylä Central Hospital, University of Eastern Finland, Jyväskylä, 40620, Finland.
Nada A Al-TassanDepartment of Genetics, King Faisal Specialist Hospital and Research Center, Riyadh, 12713, Saudi Arabia.
Claire PallesMolecular & Population Genetics Laboratory, Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, OX3 7BN, UK.
Susan M FarringtonColon Cancer Genetics Group, University of Edinburgh and MRC Human Genetics Unit, Western General Hospital, Edinburgh, EH4 2XU, UK.
Maria N TimofeevaColon Cancer Genetics Group, University of Edinburgh and MRC Human Genetics Unit, Western General Hospital, Edinburgh, EH4 2XU, UK.
Brian F MeyerDepartment of Genetics, King Faisal Specialist Hospital and Research Center, Riyadh, 12713, Saudi Arabia.
Salma M WakilDepartment of Genetics, King Faisal Specialist Hospital and Research Center, Riyadh, 12713, Saudi Arabia.
Harry CampbellCentre for Population Health Sciences, University of Edinburgh, Edinburgh, EH8 9AG, UK.
Christopher G SmithDivision of Cancer and Genetics, School of Medicine, Cardiff University, Cardiff, CF14 4XN, UK.
Shelley IdziaszczykDivision of Cancer and Genetics, School of Medicine, Cardiff University, Cardiff, CF14 4XN, UK.
Timothy S MaughanCRUK/MRC Oxford Institute for Radiation Oncology, University of Oxford, Oxford, OX3 7DQ, UK.
David FisherMRC Clinical Trials Unit, Aviation House, London, WC2B 6NH, UK.
Rachel KerrOxford Cancer Centre, Department of Oncology, University of Oxford, Churchill Hospital, Oxford, OX3 7LE, UK.
David KerrNuffield Department of Clinical Laboratory Sciences, University of Oxford, John Radcliffe Hospital, Oxford, OX3 9DU, UK.
Michael N PassarelliDepartment of Epidemiology, Geisel School of Medicine at Dartmouth, Dartmouth-Hitchcock Medical Center, Lebanon, NH, 03756, USA.
Jane C FigueiredoSamuel Oschin Comprehensive Cancer Center, Cedars-Sinai Medical Center, Los Angeles, CA, USA; Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Daniel D BuchananColorectal Oncogenomics Group, Genetic Epidemiology Laboratory, Department of Pathology, The University of Melbourne, Victoria, 3010, Australia; Centre for Epidemiology and Biostatistics, The University of Melbourne, Victoria, 3010, Australia.
Aung K WinCentre for Epidemiology and Biostatistics, The University of Melbourne, Victoria, 3010, Australia.
John L HopperCentre for Epidemiology and Biostatistics, The University of Melbourne, Victoria, 3010, Australia.
Mark A JenkinsCentre for Epidemiology and Biostatistics, The University of Melbourne, Victoria, 3010, Australia.
Noralane M LindorDepartment of Health Sciences Research, Mayo Clinic, Scottsdale, AZ, 85259, USA.
Polly A NewcombCancer Prevention Program, Fred Hutchinson Cancer Research Center, Seattle, WA, 98109, USA.
Steven GallingerLunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON, M5G 1X5, Canada.
David ContiDepartment of Preventive Medicine, University of Southern California, Los Angeles, CA, 90033, USA.
Fred SchumacherDepartment of Preventive Medicine, University of Southern California, Los Angeles, CA, 90033, USA.
Graham CaseyCenter for Public Health Genomics, University of Virginia, Charlottesville, VA, 22908, USA.
Lauri A AaltonenGenome-Scale Biology Research Program, Research Programs Unit, University of Helsinki, Helsinki, 00014, Finland; Department of Medical and Clinical Genetics, Medicum, University of Helsinki, Helsinki, 00014, Finland.
Jeremy P CheadleDivision of Cancer and Genetics, School of Medicine, Cardiff University, Cardiff, CF14 4XN, UK.
Ian P TomlinsonMolecular & Population Genetics Laboratory, Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, OX3 7BN, UK.
Malcolm G DunlopColon Cancer Genetics Group, University of Edinburgh and MRC Human Genetics Unit, Western General Hospital, Edinburgh, EH4 2XU, UK.
Richard S HoulstonDivision of Genetics and Epidemiology, The Institute of Cancer Research, London, SW7 3RP, UK. Electronic address: richard.houlston@icr.ac.uk.
University of Helsinki · FIFinnish Institute for Health and Welfare · FIInstitute of Cancer Research · GBThe University of Melbourne · AUCardiff University · GBKing Faisal Specialist Hospital & Research Centre · SAUniversity of Southern California · USWestern General Hospital · GBCentre for Human Genetics · GBHelsinki University Hospital · FIBroad Institute · USCentral Finland Health Care District · FIChurchill Hospital · GBDartmouth–Hitchcock Medical Center · USFred Hutch Cancer Center · USJohn Radcliffe Hospital · GBMayo Clinic in Arizona · USMount Sinai Hospital · CAMRC Clinical Trials Unit at UCL · GBTampere University · FI
Funding
USC Consortium:Colorectal Cancer Family RegistryU01CA074799 · NCI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI HAILE, ROBERT WILLIAM · 1997 to 2008
$20.4MSEATTLE FAMILIAL COLORECTAL CANCER REGISTRYU01CA074794 · NCI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI NEWCOMB, POLLY A · 1997 to 2007
$14.1MONTARIO REGISTRY FOR STUDIES OF FAMILIAL COLON CANCERU01CA074783 · NCI · CANCER CARE ONTARIO · PI GALLINGER, STEVEN · 1997 to 2008
$12.5MColon Cancer Family Registry CohortUM1CA167551 · NCI · STANFORD UNIVERSITY · PI HAILE, ROBERT WILLIAM, JENKINS, MARK A · 2013 to 2017
$11.3MFAMILIAL COLORECTAL NEOPLASIA COLLABORATIVE GROUPU01CA074800 · NCI · MAYO CLINIC ROCHESTER · PI LINDOR, NORALANE MOREY · 1997 to 2007
$9.1MInherited colorectal cancer risk variants: from association to biologyR01CA143237 · NCI · UNIVERSITY OF VIRGINIA · PI CASEY, GRAHAM · 2010 to 2020
$8.4MThe Colon Cancer Family Registry: USC ConsortiumU24CA074799 · NCI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI HAILE, ROBERT WILLIAM · 2008 to 2011
$7.6MGenomic Wide Association Study of Colorectal CancerU01CA122839 · NCI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI CASEY, GRAHAM · 2006 to 2010
$7.3MThe Colon Cancer Family Registry: SeattleU24CA074794 · NCI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI NEWCOMB, POLLY A · 2008 to 2011
$7.0MAUSTRALASIAN COLORECTAL CANCER FAMILY REGISTRYU01CA097735 · NCI · UNIVERSITY OF MELBOURNE · PI HOPPER, JOHN L · 2002 to 2007
$6.9MThe Colon Cancer Family Registry: AustralasiaU24CA097735 · NCI · UNIVERSITY OF MELBOURNE · PI HOPPER, JOHN L · 2008 to 2011
$6.2MHAWAII FAMILY REGISTRY OF COLON CANCERU01CA074806 · NCI · UNIVERSITY OF HAWAII AT MANOA · PI LE MARCHAND, LOIC · 1997 to 2008
$6.1MCancer Research UK 12076Cancer Research UK 15116Cancer Research UK 16459Cancer Research UK 18927Cancer Research UK C1298/A8362Cancer Research UK C348/A12076Medical Research Council MC_PC_U127527198Medical Research Council MC_U127527198Medical Research Council MR/K018647/1NCI NIH HHS HHSN261201000035CNCI NIH HHS HHSN261201000035INCI NIH HHS HHSN261201300012INCI NIH HHS N01 CN067009NCI NIH HHS N01 PC035137NCI NIH HHS N01 PC035142NCI NIH HHS R01 CA143237NCI NIH HHS U01 CA074783NCI NIH HHS U01 CA074794NCI NIH HHS U01 CA074799NCI NIH HHS U01 CA074800NCI NIH HHS U01 CA074806NCI NIH HHS U01 CA097735NCI NIH HHS U01 CA122839NCI NIH HHS U24 CA074783NCI NIH HHS U24 CA074794NCI NIH HHS U24 CA074799NCI NIH HHS U24 CA074800NCI NIH HHS U24 CA074806NCI NIH HHS U24 CA097735NCI NIH HHS UM1 CA167551NIAAA NIH HHS K02 AA018755NIAAA NIH HHS K05 AA000145NIAAA NIH HHS R01 AA012502NIAAA NIH HHS R37 AA012502NIH HHS S10 OD020069Wellcome TrustWellcome Trust 090532/Z/09/Z
Abstract
backgroundWhile dietary fat has been established as a risk factor for colorectal cancer (CRC), associations between fatty acids (FAs) and CRC have been inconsistent. Using Mendelian randomisation (MR), we sought to evaluate associations between polyunsaturated (PUFA), monounsaturated (MUFA) and saturated FAs (SFAs) and CRC risk.
methodsWe analysed genotype data on 9254 CRC cases and 18,386 controls of European ancestry. Externally weighted polygenic risk scores were generated and used to evaluate associations with CRC per one standard deviation increase in genetically defined plasma FA levels.
resultsRisk reduction was observed for oleic and palmitoleic MUFAs (OR
conclusionResults from our analysis are broadly consistent with a pro-inflammatory FA profile having a detrimental effect in terms of CRC risk.
Indexed as
Polymorphism, Single NucleotideBiomarkers, TumorCase-Control StudiesColorectal NeoplasmsDietDiet, HealthyDiet, MediterraneanFatty AcidsGene-Environment InteractionGenetic Predisposition to DiseaseGenome-Wide Association StudyHumansInflammation MediatorsMendelian Randomization AnalysisOdds RatioPhenotypeBiomarkers, TumorFatty AcidsInflammation MediatorsColorectal cancerFatty acidsMendelian randomisationPlasma fatty acidsRisk
Identifiers
What OpenQuestion holds
Textmetadata
LicenceCC BY
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.