ArticlePloS one2017
Exploratory structural assessment in craniocervical dystonia: Global and differential analyses.
Article in PloS one, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.
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Who cites it
9 citing papers in PubMed, 1 synthesis or guideline pooled it, 15 citations in OpenAlex.
- Structural magnetic resonance imaging in dystonia: A systematic review of methodological approaches and findings.European journal of neurology · 2022Pooled it
- White matter microstructural alterations correlate with clinical characteristics in craniocervical dystonia.Neuroradiology · 2026Article
- Atrophy of cerebellar lobule VI and primary motor cortex in cervical dystonia - a region of interest-based study.Journal of neural transmission (Vienna, Austria : 1996) · 2025Article
- Gray matter structural alterations of cortico-striato-thalamo-cortical loop in familial Paroxysmal Kinesigenic Dyskinesia.Heliyon · 2024Article
- Cortical and Subcortical Structural Abnormalities in Patients With Idiopathic Cervical and Generalized Dystonia.Frontiers in neuroimaging · 2022Article
- Altered Structural Brain Network Topology in Patients With Primary Craniocervical Dystonia.Frontiers in neurology · 2022Article
- Structural Brain Changes in Blepharospasm: A Cortical Thickness and Diffusion Tensor Imaging Study.Frontiers in neuroscience · 2020Article
- Multimodal Quantitative MRI Reveals No Evidence for Tissue Pathology in Idiopathic Cervical Dystonia.Frontiers in neurology · 2019Article
- Structural brain changes in people with dementia receiving Cognitive Stimulation Therapy: Preliminary findings.International journal of clinical and health psychology : IJCHPArticle
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Authors and funding
11 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionOur goal was to investigate the cortical thickness and subcortical volume in subjects with craniocervical dystonia and its subgroups.
methodsWe studied 49 subjects, 17 with cervical dystonia, 18 with blepharospasm or oromandibular dystonia, and 79 healthy controls. We performed a whole group analysis, followed by a subgroup analysis. We used Freesurfer software to measure cortical thickness, subcortical volume and to perform a primary exploratory analysis in the craniocervical dystonia group, complemented by a region of interest analysis. We also performed a secondary analysis, with data generated from Freesurfer for subgroups, corrected by false discovery rate. We then performed an exploratory generalized linear model with significant areas for the previous steps using clinical features as independent variables.
resultsThe primary exploratory analysis demonstrated atrophy in visual processing regions in craniocervical dystonia. The secondary analysis demonstrated atrophy in motor, sensory, and visual regions in blepharospasm or oromandibular dystonia, as well as in limbic regions in cervical dystonia. Cervical dystonia patients also had greater cortical thickness than blepharospasm or oromandibular dystonia patients in frontal pole and medial orbitofrontal regions. Finally, we observed an association between precuneus, age of onset of dystonia and age at the MRI exam, in craniocervical dystonia; between motor and limbic regions and age at the exam, clinical score and time on botulinum toxin in cervical dystonia and sensory regions and age of onset and time on botulinum toxin in blepharospasm or oromandibular dystonia.
conclusionsWe detected involvement of visual processing regions in craniocervical dystonia, and a pattern of involvement in cervical dystonia and blepharospasm or oromandibular dystonia, including motor, sensory and limbic areas. We also showed an association of cortical thickness atrophy and younger onset age, older age at the MRI exam, higher clinical score and an uncertain association with longer time on botulinum toxin.
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