ArticleeLife2017
Selective rab11 transport and the intrinsic regenerative ability of CNS axons.
Article in eLife, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
42 citing papers in PubMed, 73 citations in OpenAlex.
- Repressed mTORC1 signaling and transient dendritic pruning support axonal regeneration in adult zebrafish.iScience · 2026Article
- The regenerative period of somatosensory nerves is closed by a DCC signaling axis.PLoS genetics · 2026Article
- Microtubule dynamics in adult retinal ganglion cells and dorsal root ganglion neurons.Frontiers in molecular neuroscience · 2026Article
- Axon-specific microtubule regulation drives asymmetric regeneration of sensory neuron axons.eLife · 2025Article
- Hyperactive delta isoform of PI3 kinase enables long-distance regeneration of adult rat corticospinal tract.Molecular therapy : the journal of the American Society of Gene Therapy · 2025Article
- Neuronal maturation and axon regeneration: unfixing circuitry to enable repair.Nature reviews. Neuroscience · 2024Review
- Integrin-Driven Axon Regeneration in the Spinal Cord Activates a Distinctive CNS Regeneration Program.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Review
- Single Nuclei Analyses Reveal Transcriptional Profiles and Marker Genes for Diverse Supraspinal Populations.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
- Rabphilin3A reduces integrin-dependent growth cone signaling to restrict axon regeneration after trauma.Experimental neurology · 2022Article
- Promoting axon regeneration in the central nervous system by increasing PI3-kinase signaling.Neural regeneration research · 2022Review
- Quantitative BONCAT Allows Identification of Newly Synthesized Proteins after Optic Nerve Injury.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
- The Role of ATF3 in Neuronal Differentiation and Development of Neuronal Networks in Opossum Postnatal Cortical Cultures.International journal of molecular sciences · 2022Article
- Integrin Signaling in the Central Nervous System in Animals and Human Brain Diseases.International journal of molecular sciences · 2022Review
- Long-Term Cultures of Spinal Cord Interneurons.Frontiers in cellular neuroscience · 2022Article
- TC10 as an essential molecule in axon regeneration through membrane supply and microtubule stabilization.Neural regeneration research · 2022Article
- Transport and Secretion of the Wnt3 Ligand by Motor Neuron-like Cells and Developing Motor Neurons.Biomolecules · 2021Article
- Age-related loss of axonal regeneration is reflected by the level of local translation.Experimental neurology · 2021Article
- Combined kinesin-1 and kinesin-3 activity drives axonal trafficking of TrkB receptors in Rab6 carriers.Developmental cell · 2021Article
- Axonal Organelles as Molecular Platforms for Axon Growth and Regeneration after Injury.International journal of molecular sciences · 2021Review
Corrections and comments
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Authors and funding
10 authors at 3 institutions in 2 countries.
Funding
Abstract
Neurons lose intrinsic axon regenerative ability with maturation, but the mechanism remains unclear. Using an in-vitro laser axotomy model, we show a progressive decline in the ability of cut CNS axons to form a new growth cone and then elongate. Failure of regeneration was associated with increased retraction after axotomy. Transportation into axons becomes selective with maturation; we hypothesized that selective exclusion of molecules needed for growth may contribute to regeneration decline. With neuronal maturity rab11 vesicles (which carry many molecules involved in axon growth) became selectively targeted to the somatodendritic compartment and excluded from axons by predominant retrograde transport However, on overexpression rab11 was mistrafficked into proximal axons, and these axons showed less retraction and enhanced regeneration after axotomy. These results suggest that the decline of intrinsic axon regenerative ability is associated with selective exclusion of key molecules, and that manipulation of transport can enhance regeneration.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.