ArticleACS chemical biology2017
Chemical Interrogation of LuxR-type Quorum Sensing Receptors Reveals New Insights into Receptor Selectivity and the Potential for Interspecies Bacterial Signaling.
Article in ACS chemical biology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Drug-resistantClinical microbiology reviews · 2025Pooled it
- γ-Butyrolactones and γ-butenolides as autoregulatory systems: key mediators of intraspecific, interspecific, and interkingdom communication in Streptomyces.Archives of microbiology · 2026Review
- Correction to "Chemical Probes That Target a Dissociative LuxR-Type Quorum Sensing Receptor in Gram-Negative Bacteria".ACS chemical biology · 2025Article
- Chemical Probes that Target a Dissociative LuxR-Type Quorum Sensing Receptor in Gram-Negative Bacteria.ACS chemical biology · 2025Article
- Cyanuric acid in Paramecium secretions is an efficient quorum sensing inducer.The ISME journal · 2025Article
- Synthesis of Gamma-Butyrolactone Hormones Enables Understanding of Natural Product Induction.ACS chemical biology · 2023Article
- Natural and synthetic inhibitors of a phage-encoded quorum-sensing receptor affect phage-host dynamics in mixed bacterial communities.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Signal Transduction Network Principles Underlying Bacterial Collective Behaviors.Annual review of microbiology · 2022Review
- The Association between Biofilm Formation and Antimicrobial Resistance with Possible Ingenious Bio-Remedial Approaches.Antibiotics (Basel, Switzerland) · 2022Review
- Molecular simulations of lipid membrane partitioning and translocation by bacterial quorum sensing modulators.PloS one · 2021Article
- Chemical Control of Quorum Sensing inACS infectious diseases · 2020Article
- Mechanism underlying autoinducer recognition in theThe Journal of biological chemistry · 2020Article
- Omics Technologies to Understand Activation of a Biosynthetic Gene Cluster in Micromonospora sp. WMMB235: Deciphering Keyicin Biosynthesis.ACS chemical biology · 2019Article
- Article
- Genome analysis of a thermophilic exopolysaccharide-producing bacterium - Geobacillus sp. WSUCF1.Scientific reports · 2019Article
- Structural determinants driving homoserine lactone ligand selection in theProceedings of the National Academy of Sciences of the United States of America · 2019Article
- Small Molecule Anti-biofilm Agents Developed on the Basis of Mechanistic Understanding of Biofilm Formation.Frontiers in chemistry · 2019Review
- Non-native autoinducer analogs capable of modulating the SdiA quorum sensing receptor inBeilstein journal of organic chemistry · 2018Article
- Article
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Authors and funding
7 authors.
Funding
Abstract
Cell-cell signaling between bacteria, including quorum-sensing (QS) communication systems, may play a role in the establishment and maintenance of polymicrobial communities. To better understand and model these interactions, we must uncover the degree to which neighboring species recognize each another's signals. In the current study, we tested the likelihood of whether the QS systems of two opportunistic pathogens (Acinetobacter baumannii and Pseudomonas aeruginosa) that frequently arise in polymicrobial infections would be affected by the QS signals of neighboring species. Through the synthesis and screening of a library of native and non-native N-acyl l-homoserine lactones (AHLs), we found that the AbaR LuxR-type receptor protein of A. baumannii is highly selective for its native AHL signal. However, a homologous LuxR-type receptor in P. aeruginosa, LasR, is far more promiscuously activated by AHLs relative to AbaR, suggesting that LasR-regulated QS could be more susceptible to activation by neighboring species. To explain the observed difference in signal selectivity between AbaR and LasR, we developed a model based on (i) the activity profiles of these proteins and (ii) previously reported structural data and activity profiles for related LuxR-type receptors. This model may facilitate the study of signal selectivities for hundreds of LuxR-type QS receptors from bacteria, many of which grow in polymicrobial communities and may sense each other's signals. In addition, we discovered a set of AHLs that could be used to selectively activate LasR and selectively inhibit AbaR in polymicrobial experiments.
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