ArticleNutrients2017
The Anti-Inflammatory and Antioxidant Potential of Pistachios (Pistacia vera L.) In Vitro and In Vivo.
Article in Nutrients, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
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Who cites it
37 citing papers in PubMed, 86 citations in OpenAlex.
- Protective effects of pistachio pericarp essential oil against diazinon-induced oxidative stress and follicular damage in the ovaries of NMRI mice.Journal of ovarian research · 2026Article
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- Phytochemical profiling and anticancer potential of pistachio wastes against MCF-7 breast cancer cells: a metabolic and apoptotic pathway analysis.BMC complementary medicine and therapies · 2025Article
- Analysis of gene expansion and defense-related genes in Anacardiaceae family from an evolutionary aspect.Frontiers in plant science · 2025Article
- Protective Effect of Probiotics againstInternational journal of molecular sciences · 2024Article
- The Cardioprotective Properties of Selected Nuts: Their Functional Ingredients and Molecular Mechanisms.Foods (Basel, Switzerland) · 2024Review
- Prolyl oligopeptidase inhibition ameliorates experimental pulmonary fibrosis both in vivo and in vitro.Respiratory research · 2023Article
- Antioxidant Activity of a Sicilian Almond Skin Extract Using In Vitro and In Vivo Models.International journal of molecular sciences · 2023Article
- Targeting Nrf2 and NF-κB Signaling Pathways in Inflammatory Pain: The Role of Polyphenols from Thinned Apples.Molecules (Basel, Switzerland) · 2023Article
- Immunometabolism Modulation by Extracts from Pistachio Stalks Formulated in Phospholipid Vesicles.Pharmaceutics · 2023Article
- Believe It or 'Nutrients · 2023Review
- Mediterranean Diet and Melatonin: A Systematic Review.Antioxidants (Basel, Switzerland) · 2023Review
- Plant bioactive compounds from Mediterranean diet improve risk factors for metabolic syndrome.International journal of food sciences and nutrition · 2023Review
- Why Should Pistachio Be a Regular Food in Our Diet?Nutrients · 2022Review
- The current status of old traditional medicine introduced from Persia to China.Frontiers in pharmacology · 2022Review
- Mosloflavone-Resveratrol Hybrid TMS-HDMF-5z Exhibits PotentFrontiers in pharmacology · 2022Article
- Pistachio Nuts (Plants (Basel, Switzerland) · 2021Review
- Advances in Research on Chemical Constituents and Their Biological Activities of the Genus Actinidia.Natural products and bioprospecting · 2021Review
- Beneficial role of Pistacia lentiscus aqueous extract in experimental colitis: anti-inflammatory and potential therapeutic effects.Inflammopharmacology · 2021Article
- Health Benefits Related to Tree Nut Consumption and Their Bioactive Compounds.International journal of molecular sciences · 2021Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Several reports have demonstrated the effectiveness of pistachio against oxidative stress and inflammation. In this study, we investigate if polyphenols extracts from natural raw shelled pistachios (NP) or roasted salted pistachio (RP) kernels have anti-inflammatory and antioxidant properties at lower doses than reported previously, in both in vitro and in vivo models. The monocyte/macrophage cell line J774 was used to assess the extent of protection by NP and RP pistachios against lipopolysaccharide (LPS)-induced inflammation. Moreover, antioxidant activity of NP and RP was assessed in an in vivo model of paw edema in rats induced by carrageenan (CAR) injection in the paw. Results from the in vitro study demonstrated that pre-treatment with NP (0.01, 0.1 and 0.5 mg/mL) and RP (0.01 and 0.1 mg/mL) exerted a significant protection against LPS induced inflammation. Western blot analysis showed NP reduced the degradation of IκB-α, although not significantly, whereas both NP and RP decreased the TNF-α and IL-1β production in a dose-dependent way. A significant reduction of CAR-induced histological paw damage, neutrophil infiltration and nitrotyrosine formation was observed in the rats treated with NP. These data demonstrated that, at lower doses, polyphenols present in pistachios possess antioxidant and anti-inflammatory properties. This may contribute toward a better understanding of the beneficial health effects associated with consumption of pistachios.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.