Evidence map›Paper›PMID 28829039›Full record

ArticleeLife2017

Dynamics and consequences of spliceosome E complex formation.

Joshua Donald Larson, Aaron A Hoskins

Open access · goldAbstract read
In one paragraph

Article in eLife, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed
1.3field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 39 citations in OpenAlex.

  1. Review
  2. Article
  3. International journal of molecular sciences · 2025
    Article
  4. Article
  5. Review
  6. Article
  7. Article
  8. Article
  9. Functional Analysis of the Zinc Finger Modules of thebioRxiv : the preprint server for biology · 2024
    Article
  10. Article
  11. Article
  12. Early Splicing Complexes and Human Disease.International journal of molecular sciences · 2023
    Review
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Joshua Donald LarsonDepartment of Biochemistry, University of Wisconsin-Madison, Madison, United States.
Aaron A HoskinsDepartment of Biochemistry, University of Wisconsin-Madison, Madison, United States.ORCID http://orcid.org/0000-0002-9777-519X
University of Wisconsin–Madison · US

Funding

Mechanisms of Spliceosome Assembly and Splice Site RecognitionR01GM112735 · NIGMS · UNIVERSITY OF WISCONSIN-MADISON · PI HOSKINS, AARON ANDREW · 2015 to 2019
$1.6M
Mechanisms of Spliceosome Assembly and Splice Site SelectionR00GM086471 · NIGMS · UNIVERSITY OF WISCONSIN-MADISON · PI HOSKINS, AARON ANDREW · 2011 to 2013
$733k
NIGMS NIH HHS R00 GM086471NIGMS NIH HHS R01 GM112735
6 · The paper itself

Abstract

The spliceosome must identify the correct splice sites (SS) and branchsite (BS) used during splicing. E complex is the earliest spliceosome precursor in which the 5' SS and BS are defined. Definition occurs by U1 small nuclear ribonucleoprotein (snRNP) binding the 5' SS and recognition of the BS by the E complex protein (ECP) branchpoint bridging protein (BBP). We have used single molecule fluorescence to study

Indexed as

Protein MultimerizationKineticsProtein BindingRibonucleoprotein, U1 Small NuclearRNA, FungalRNA PrecursorsRNA Splicing FactorsSaccharomyces cerevisiaeSaccharomyces cerevisiae ProteinsSingle Molecule ImagingSpliceosomesMSL5 protein, S cerevisiaeRibonucleoprotein, U1 Small NuclearRNA, FungalRNA PrecursorsRNA Splicing FactorsSaccharomyces cerevisiae ProteinsbiochemistrybiophysicsCoSMoSRNAS. cerevisiaesingle molecule fluorescencesnRNPspliceosomesplicingstructural biology

Identifiers

PMID28829039
PMCPMC5779234
OpenAlexW2749430170

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.