Evidence map›Paper›PMID 28828966›Full record

ArticleNeurological research2017

Chronic cerebral hypoperfusion induced by bilateral carotid artery stenosis causes selective recognition impairment in adult mice.

Arati Patel, Alimohammad Moalem, Hank Cheng, Robin M Babadjouni, Kaleena Patel, Drew M Hodis, Deep Chandegara, Steven Cen, Shuhan He, Qinghai Liu and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neurological research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. A brief overview of a mouse model of cerebral hypoperfusion by bilateral carotid artery stenosis.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2023
    Review
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
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  17. Article
  18. Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Arati Patela Keck School of Medicine , University of Southern California , Los Angeles , CA , USA.ORCID http://orcid.org/0000-0002-2300-0391
Alimohammad Moalema Keck School of Medicine , University of Southern California , Los Angeles , CA , USA.
Hank Chengb Zilkha Neurogenetic Institute , University of Southern California , Los Angeles , CA , USA.
Robin M Babadjounia Keck School of Medicine , University of Southern California , Los Angeles , CA , USA.ORCID http://orcid.org/0000-0002-5048-9233
Kaleena Patela Keck School of Medicine , University of Southern California , Los Angeles , CA , USA.
Drew M Hodisb Zilkha Neurogenetic Institute , University of Southern California , Los Angeles , CA , USA.
Deep Chandegaraa Keck School of Medicine , University of Southern California , Los Angeles , CA , USA.
Steven Cena Keck School of Medicine , University of Southern California , Los Angeles , CA , USA.
Shuhan Hea Keck School of Medicine , University of Southern California , Los Angeles , CA , USA.
Qinghai Liub Zilkha Neurogenetic Institute , University of Southern California , Los Angeles , CA , USA.
William J Macka Keck School of Medicine , University of Southern California , Los Angeles , CA , USA.

Funding

Neurotoxicity of Airborne Particles: Role of Chronic Cerebral HypoperfusionR01ES024936 · NIEHS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI MACK, WILLIAM J · 2015 to 2019
$2.4M
NIEHS NIH HHS R01 ES024936
6 · The paper itself

Abstract

objectivesChronic cerebral hypoperfusion (CCH) can result in vascular dementia and small vessel white matter ischemic injury. These findings have previously been demonstrated in a murine experimental model of CCH secondary to bilateral common carotid artery stenosis (BCAS). This study sought to elucidate the effects of CCH on recognition memory as assessed by the novel object recognition (NOR) test and histological analysis of the hippocampus and perirhinal cortex.

methodsStudies were performed on ten-week-old male mice using bilateral 0.18 mm microcoils to narrow the carotid arteries in accordance with prior publications. Following surgery, BCAS (n = 6) and sham (n = 6) mice were evaluated using NOR and 8-arm radial maze testing paradigms. Tissue damage was assessed using H&E staining on a parallel cohort of mice (n = 6 BCAS, n = 7 sham).

resultsIn the NOR paradigm, BCAS mice demonstrated significant deficits in short-term memory. Consistent with prior studies, BCAS mice also performed significantly worse on 8-arm radial maze testing. BCAS mice exhibited significantly more neuronal injury in the perirhinal cortex when compared to sham-operated mice. However, no significant differences in neuronal damage were observed in the CA1 region of the hippocampus. DISCUSSION: Experimental CCH secondary to BCAS results in recognition memory deficits on NOR testing. Damage to the perirhinal cortex, rather than to the hippocampus, may underlie this impairment.

Indexed as

AnimalsCA1 Region, HippocampalCarotid StenosisCerebrovascular CirculationChronic DiseaseDementia, VascularDisease Models, AnimalMaleMaze LearningMemory, Short-TermMice, Inbred C57BLNeuronsPerirhinal CortexRecognition, PsychologyhypoperfusionIschemianovel object recognitionperirhinal cortexshort-term memory

Identifiers

PMID28828966
PMCPMC5591078

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.