Evidence map›Paper›PMID 28828963›Full record

ArticleHIV clinical trials2017

Soluble TWEAK may predict carotid atherosclerosis in treated HIV infection.

Sahera Dirajlal-Fargo, Abdus Sattar, Manjusha Kulkarni, Nicholas Funderburg, Grace A McComsey

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in HIV clinical trials, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.3field-weighted citation impact, top 45% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Sahera Dirajlal-Fargoa Department of Pediatrics , Case Western Reserve University , Cleveland , OH , USA.
Abdus Sattara Department of Pediatrics , Case Western Reserve University , Cleveland , OH , USA.
Manjusha Kulkarnic Division of Medical Laboratory Science, School of Health and Rehabilitation Sciences , Ohio State University , Columbus , OH , USA.
Nicholas Funderburgc Division of Medical Laboratory Science, School of Health and Rehabilitation Sciences , Ohio State University , Columbus , OH , USA.
Grace A McComseya Department of Pediatrics , Case Western Reserve University , Cleveland , OH , USA.
Case Western Reserve University · USThe Ohio State University · US

Funding

WG3: HIV, Co-infections and Co-morbiditiesP30AI036219 · NIAID · CASE WESTERN RESERVE UNIVERSITY · PI Mark James Cameron · 1994 to 2026
$50.0M
Dysregulated arginine metabolism in treated HIV infectionR56HL126539 · NHLBI · CASE WESTERN RESERVE UNIVERSITY · PI MCCOMSEY, GRACE A · 2014 to 2014
$792k
Incremental effect of smoking on HIV immune activation and cardiac healthR56HL126526 · NHLBI · CASE WESTERN RESERVE UNIVERSITY · PI MCCOMSEY, GRACE A · 2014 to 2014
$788k
Tissue factor expression in HIV disease - Implications for cardiovascular riskR00HL108743 · NHLBI · OHIO STATE UNIVERSITY · PI FUNDERBURG, NICHOLAS T. · 2014 to 2016
$747k
NHLBI NIH HHS R00 HL108743NHLBI NIH HHS R56 HL126526NHLBI NIH HHS R56 HL126539NIAID NIH HHS P30 AI036219
6 · The paper itself

Abstract

backgroundSoluble Tumor Necrosis Factor Weak Inducer of Apoptosis (sTWEAK) has been proposed as a novel biomarker of cardiovascular disease risk. This study compares levels of sTWEAK, sCD163 and the sCD163/sTWEAK ratio in HIV-infected and uninfected patients and their associations with cardiovascular and inflammatory factors.

methodsThe data for our analysis come from 274 HIV-infected adults and 59 controls. HIV participants were on stable antiretroviral therapy (ART). Wilcoxon-Mann-Whitney tests were used for comparing markers between HIV-infected participants with HIV viral load <50 copies/mL (aviremic group), HIV-infected participants with detectable viremia (HIV-1 RNA ≥50 copies/mL; viremic group) and HIV negative participants. Multivariable quantile regression analyses were used to assess associations of sTWEAK and sCD163 with other markers of inflammation and carotid intima-media thickness (cIMT).

resultsOverall, 74% of participants were male; 59% were African-Americans; median age was 40 years and CD4 595 cells/mm3. Overall, HIV-infected participants had reduced sTWEAK and increased sCD163 levels compared to HIV-uninfected participants (p = 0.0001 for both markers). In addition, these biomarkers were significantly different between HIV-infected viremic and aviremic patients (p ≤ 0.01 for both markers). In multivariable models, sTWEAK and sCD163 in aviremic patients were significantly correlated with common carotid artery IMT (p ≤ 0.05). In HIV-infected aviremic participants, sTWEAK and sCD163 were both associated with IL-6, CD14 + CD16 + monocytes (p ≤ 0.02); additionally, sCD163 was associated with D-dimer- (β = -69.5, 0.05), VCAM (β = 72.4, p = 0.05), TNF RI (β = 91.1, p < 0.01), and TNF RII (β = 87.8, p < 0.01).

conclusionsHIV-infected participants showed increased systemic inflammatory and monocyte activation markers. Soluble CD163 and sTWEAK levels were associated with carotid intima-media thickness.

Indexed as

AdultAntigens, CDAntigens, Differentiation, MyelomonocyticBiomarkersCarotid Artery DiseasesCarotid Intima-Media ThicknessCD163 AntigenCytokinesCytokine TWEAKFemaleHIV InfectionsHumansInflammation MediatorsLymphocyte ActivationMaleMiddle AgedAntigens, CDAntigens, Differentiation, MyelomonocyticBiomarkersCD163 AntigenCytokinesCytokine TWEAKInflammation MediatorsReceptors, Cell SurfaceTNFSF12 protein, humanCardiovascular diseaseImmune activationInflammation

Identifiers

PMID28828963
PMCPMC8559006
OpenAlexW2750352649

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.