ArticlePsychopharmacology2017
Role of early environmental enrichment on the social dominance tube test at adulthood in the rat.
Article in Psychopharmacology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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8 citing papers in PubMed, 33 citations in OpenAlex.
- Developmental functions of microglia: Impact of psychosocial and physiological early life stress.Neuropharmacology · 2024Review
- Audiogenic Seizures and Social Deficits: No Aggravation Found in Krushinsky-Molodkina Rats.Biomedicines · 2023Article
- Chronic social comparison elicits depression- and anxiety-like behaviors and alterations in brain-derived neurotrophic factor expression in male rats.Animal cognition · 2023Article
- Potential Therapeutic Effects of NAMPT-Mediated NAD Biosynthesis in Depression In Vivo.Brain sciences · 2022Article
- Environmental enrichment improves lifelong persistent behavioral and epigenetic changes induced by early-life stress.Journal of psychiatric research · 2021Article
- Maternal Separation Early in Life Alters the Expression of GenesBehavioural neurology · 2020Article
- Conspecific Presence Improves Episodic-Like Memory in Rats.Frontiers in behavioral neuroscience · 2020Article
- Using the tube test to measure social hierarchy in mice.Nature protocols · 2019Article
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Authors and funding
13 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
rationaleEnvironmental enrichment (EE) could influence brain plasticity and behavior in rodents. Whether the early EE may predispose individuals to a particular social hierarchy in the social dominance tube test (SDTT) at adulthood is still unknown.
objectiveThe present study directly investigated the influence of EE on competitive success in the SDTT among adult rats.
methodsMale rats were maintained in EE from postnatal days 21 to 35. Social dominance behavior was determined by SDTT, competitive food foraging test, and mate preference test at adulthood. IBA-1 expression in the hypothalamus was examined using immunohistochemistry and western blot.
resultsEE rats were prone to become submissive during a social encounter with standard environment (SE) rats in the SDTT. No difference was found in food foraging in the competitive food foraging test between SE and EE rats. Male EE rats were more attractive than the SE to the female rats in the mate preference test. IBA-1 expression was found to be decreased in the hypothalamus of EE rats compared to SE group. Infusion of a microglia inhibitor reduced percentage of forward in SE rats in the SDTT. Infusion of DNA methyltransferase inhibitor prevented the development of subordinate status in EE rats and restored the expression of IBA-1 in the hypothalamus.
conclusionsThe results suggest that early EE did not lead to reduced social hierarchy in the male rat. However, EE caused a reduction in the percentage of forward in the SDTT, which might be associated with reduced number of microglia in the hypothalamus.
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