Evidence map›Paper›PMID 28828403›Full record

ArticleeNeuro

Stress Increases Peripheral Axon Growth and Regeneration through Glucocorticoid Receptor-Dependent Transcriptional Programs.

Jessica K Lerch, Jessica K Alexander, Kathryn M Madalena, Dario Motti, Tam Quach, Akhil Dhamija, Alicia Zha, John C Gensel, Jeanette Webster Marketon, Vance P Lemmon and 2 more

Open access · goldAbstract read
In one paragraph

Article in eNeuro. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed
2.0field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 48 citations in OpenAlex.

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  10. Confronting the loss of trophic support.Frontiers in molecular neuroscience · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 5 institutions in 1 country.

Jessica K LerchCenter for Brain and Spinal Cord Repair, Department of Neuroscience, Wexner Medical Center at the Ohio State University, Columbus, OH 43210.ORCID 0000-0002-1210-3184
Jessica K AlexanderCenter for Brain and Spinal Cord Repair, Department of Neuroscience, Wexner Medical Center at the Ohio State University, Columbus, OH 43210.
Kathryn M MadalenaCenter for Brain and Spinal Cord Repair, Department of Neuroscience, Wexner Medical Center at the Ohio State University, Columbus, OH 43210.
Dario MottiThe Miami Project to Cure Paralysis, Department of Neurological Surgery, The University of Miami, Miami, FL 33136.
Tam QuachCenter for Brain and Spinal Cord Repair, Department of Neuroscience, Wexner Medical Center at the Ohio State University, Columbus, OH 43210.
Akhil DhamijaCenter for Brain and Spinal Cord Repair, Department of Neuroscience, Wexner Medical Center at the Ohio State University, Columbus, OH 43210.ORCID 0000-0002-9822-2175
Alicia ZhaCenter for Brain and Spinal Cord Repair, Department of Neuroscience, Wexner Medical Center at the Ohio State University, Columbus, OH 43210.
John C GenselCenter for Brain and Spinal Cord Repair, Department of Neuroscience, Wexner Medical Center at the Ohio State University, Columbus, OH 43210.ORCID 0000-0001-8980-108X
Jeanette Webster MarketonSRA International Inc, Beavercreek, OH 45431.
Vance P LemmonThe Miami Project to Cure Paralysis, Department of Neurological Surgery, The University of Miami, Miami, FL 33136.ORCID 0000-0003-3550-7576
John L BixbyThe Miami Project to Cure Paralysis, Department of Neurological Surgery, The University of Miami, Miami, FL 33136.ORCID 0000-0003-1633-5318
Phillip G PopovichCenter for Brain and Spinal Cord Repair, Department of Neuroscience, Wexner Medical Center at the Ohio State University, Columbus, OH 43210.ORCID 0000-0003-1329-7395
The Ohio State University Wexner Medical Center · USUniversity of Miami · USNationwide Children's Hospital · USSRA International (United States) · USUniversity of Kentucky · US

Funding

Novel Gene Targets for CNS Axonal RegenerationR01HD057632 · NICHD · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI BIXBY, JOHN L, LEMMON, VANCE P · 2007 to 2018
$4.7M
Preventing autonomic dysreflexia to restore immune function after SCIR01NS083942 · NINDS · OHIO STATE UNIVERSITY · PI POPOVICH, PHILLIP G · 2014 to 2018
$2.2M
NICHD NIH HHS R01 HD057632NINDS NIH HHS R01 NS083942
6 · The paper itself

Abstract

Stress and glucocorticoid (GC) release are common behavioral and hormonal responses to injury or disease. In the brain, stress/GCs can alter neuron structure and function leading to cognitive impairment. Stress and GCs also exacerbate pain, but whether a corresponding change occurs in structural plasticity of sensory neurons is unknown. Here, we show that in female mice (

Indexed as

Activating Transcription Factor 3AnimalsAxonsCalcium-Binding ProteinsDisease Models, AnimalFemaleGanglia, SpinalGreen Fluorescent ProteinsHormone AntagonistsIntracellular Signaling Peptides and ProteinsMiceMice, Inbred C57BLMice, TransgenicMifepristoneNerve RegenerationNerve Tissue ProteinsActivating Transcription Factor 3Atf3 protein, mouseCalcium-Binding ProteinsGreen Fluorescent ProteinsHormone AntagonistsIntracellular Signaling Peptides and ProteinsMifepristoneNerve Tissue ProteinsReceptors, GlucocorticoidStathminStmn2 protein, mouseglucocorticoid receptorKey Words: dorsal root gangliaplasticitystress

Identifiers

PMID28828403
PMCPMC5563843
OpenAlexW2742992985

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.