ReviewAnnals of translational medicine2017
High-flow nasal oxygen therapy and noninvasive ventilation in the management of acute hypoxemic respiratory failure.
Review in Annals of translational medicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04998383 (HVNI vs Noninvasive Ventilation for Acute Hypercapnic Respiratory Failure), which is not on this map. Cited by 68 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
HVNI vs Noninvasive Ventilation for Acute Hypercapnic Respiratory Failure
Who cites it
68 citing papers in PubMed, 4 syntheses or guidelines pooled it, 168 citations in OpenAlex.
- Noninvasive oxygenation and ventilation strategies for viral acute respiratory failure: a comprehensive systematic review and meta-analysis.Systematic reviews · 2025Pooled it
- High-flow nasal oxygen therapy compared with conventional oxygen therapy in hospitalised patients with respiratory illness: a systematic review and meta-analysis.BMJ open respiratory research · 2024Pooled it
- ROX index as a good predictor of high flow nasal cannula failure in COVID-19 patients with acute hypoxemic respiratory failure: A systematic review and meta-analysis.Journal of critical care · 2021Pooled it
- The efficacy and tolerance of prone positioning in non-intubation patients with acute hypoxemic respiratory failure and ARDS: a meta-analysis.Therapeutic advances in respiratory diseasePooled it
- Trial
- Clinical efficacy of high-flow nasal humidified oxygen therapy in patients with hypoxemia.PloS one · 2019Trial
- Hemodynamic and ventilatory effects of stepwise head-of-bed elevation in acute respiratory distress syndrome patients undergoing high-flow nasal cannula: a prospective sequential physiological study.Journal of thoracic disease · 2026Article
- Preoxygenation When Standard Approaches Fail: Phenotype-Based Strategies for High-Risk Emergent Intubations.Journal of clinical medicine · 2026Review
- Role of High flow nasal cannula in managing Type I respiratory failure in patients with neuromuscular disorders.BMC pulmonary medicine · 2026Article
- High-flow nasal-cannula oxygen therapy in intensive-care-unit patients: a prospective multicenter observational cohort study (OHE-REA).Scientific reports · 2026Observational
- High-flow nasal therapy vs conventional oxygen therapy in mild COVID-19 hypoxaemia: a Bayesian reanalysis of the COVID-HIGH Trial.Journal of anesthesia, analgesia and critical care · 2026Article
- Clinical effectiveness of high-flow nasal cannula oxygen therapy in post-cardiac surgery hypoxemia: A retrospective cohort study.Medicine · 2026Article
- CPAP and high-flow nasal oxygen also reduce lung, diaphragm, and accessory muscle injury in experimental self-inflicted lung injury.Scientific reports · 2026Article
- Respiratory Support in Cardiogenic Pulmonary Edema: Clinical Insights from Cardiology and Intensive Care.Journal of cardiovascular development and disease · 2026Review
- Outcomes of Noninvasive Positive Pressure Ventilation via RAM Cannula in Pediatric Intensive Care: A Preliminary Report.International journal of pediatrics · 2026Article
- A Mixed Methods Study of Inpatients' Experiences, Priorities, and Health-Related Quality of Life During High-Flow Nasal Cannula Therapy.Journal of patient-centered research and reviews · 2026Article
- High-flow Oxygen and Nitric Oxide inhalation versus high-flow oxygen alone to prevent intubation in hypoxaemic Respiratory failure (HONOR): a pilot randomised controlled trial protocol.Pilot and feasibility studies · 2025Article
- Early Prediction of High-flow Nasal Cannula Failure Using Pediatric-modified HACOR Score in Children with Acute Hypoxemic Respiratory Distress: A Prospective Observational Study.Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine · 2025Article
- High-Flow Nasal Cannula in Weaning Patients from Mechanical Ventilation in Head and Neck Surgery: Retrospective Study.Life (Basel, Switzerland) · 2025Article
- Implementation of High-Flow Oxygen Therapy in a Surgical High-Dependency Unit: A Cohort Study.Cureus · 2025Article
8 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
High-flow nasal cannula (HFNC) oxygen therapy is a recent technique delivering a high flow of heated and humidified gas. HFNC is simpler to use and apply than noninvasive ventilation (NIV) and appears to be a good alternative treatment for hypoxemic acute respiratory failure (ARF). HFNC is better tolerated than NIV, delivers high fraction of inspired oxygen (FiO
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.