ArticlePeerJ2017
Exercise training with dietary restriction enhances circulating irisin level associated with increasing endothelial progenitor cell number in obese adults: an intervention study.
Article in PeerJ, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
23 citing papers in PubMed, 36 citations in OpenAlex.
- Effect of Roux-en-Y Gastric Bypass Surgery and Restricted Diet on Endothelial Progenitor Cells in Egyptian Subjects with Morbid Obesity.Obesity surgery · 2026Trial
- Aquatic High-Intensity Interval Training Improves Vascular Function, Whereas Aquatic Moderate-Intensity Continuous Training Lowers Resting Heart Rate in Overweight and Obese Young Adults: A Randomized Controlled Trial.Journal of sports science & medicine · 2025Trial
- Trial
- Long-term aerobic exercise enhances circulating exosomal miR-214-3p to promote endothelial progenitor cell-mediated repair of endothelial damage induced by obesity.Journal of sport and health science · 2025Article
- Acute high-intensity interval exercise is superior to moderate-intensity continuous exercise in enhancing endothelial function and its associated biomarkers in sedentary young individuals: the possible involvement of lactate.Journal of exercise science and fitness · 2025Article
- TRIM27 Promotes Endothelial Progenitor Cell Apoptosis in Patients with In-Stent Restenosis by Ubiquitinating TBK1.Applied biochemistry and biotechnology · 2024Article
- Long-term effects of COVID-19 on endothelial function, arterial stiffness, and blood pressure in college students: a pre-post-controlled study.BMC infectious diseases · 2024Article
- The emerging roles of irisin in vascular calcification.Frontiers in endocrinology · 2024Review
- The role and underlying mechanisms of irisin in exercise-mediated cardiovascular protection.PeerJ · 2024Review
- Irisin Regulates Cardiac Responses to Exercise in Health and Diseases: a Narrative Review.Journal of cardiovascular translational research · 2023Review
- Association of Plasma Irisin Levels with Circulating Endothelial Microparticles (EMPs) and Endothelial Progenitor Cells (EPCs) in Children Born Prematurely.Metabolites · 2023Article
- Obesity and Endothelial Function.Biomedicines · 2022Review
- Effects of aquatic high-intensity interval training and moderate-intensity continuous training on central hemodynamic parameters, endothelial function and aerobic fitness in inactive adults.Journal of exercise science and fitness · 2022Article
- Long-Term Effect of Exercise on Irisin Blood Levels-Systematic Review and Meta-Analysis.Healthcare (Basel, Switzerland) · 2021Review
- Exercise Training Improves Functions of Endothelial Progenitor Cells in Patients with Metabolic Syndrome.Arquivos brasileiros de cardiologia · 2021Article
- The Role of Exercise, Diet, and Cytokines in Preventing Obesity and Improving Adipose Tissue.Nutrients · 2021Review
- Six-Week Exercise Training With Dietary Restriction Improves Central Hemodynamics Associated With Altered Gut Microbiota in Adolescents With Obesity.Frontiers in endocrinology · 2020Article
- The Role of PGC-1α/UCP2 Signaling in the Beneficial Effects of Physical Exercise on the Brain.Frontiers in neuroscience · 2019Review
- Effects Of Exercise Training With Dietary Restriction On Arterial Stiffness, Central Hemodynamic Parameters And Cardiac Autonomic Function In Obese Adolescents.Diabetes, metabolic syndrome and obesity : targets and therapy · 2019Article
- Irisin in metabolic diseases.Endocrine · 2018Review
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveCirculating endothelial progenitor cells (EPCs) correlate negatively with obesity. Previous studies have shown that exercise significantly restores circulating EPC levels in obese people; however, the underlying mechanisms have not been elucidated. Recently, irisin has been reported to have a critical role in the regulation of EPCs. This exercise-induced myokine has been demonstrated to play a therapeutic role in obesity. In this study, we hypothesized that the increase in circulating irisin may form a link with increasing EPC levels in obese people after exercise.
methodsSeventeen obese adults completed an 8-week program of combined exercise and dietary intervention. Clinical characteristics, blood biochemistry, and circulating irisin levels of subjects were measured before and after eight weeks of training. EPC levels were evaluated via flow cytometry, and EPC migratory and adhesive functions were also determined.
resultsCirculating irisin levels significantly increased following the 8-week training program ( DISCUSSION: For the first time, a positive correlation between increasing irisin levels and increasing EPC levels has been reported after an 8-week program, consisting of exercise and dietary intervention. This result suggests a novel effect of irisin on the regulation of EPC mobilization, which might contribute to improvement of endothelial function in obese people.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.