ArticlePeerJ2017
Periodontal inflammatory disease is associated with the risk of Parkinson's disease: a population-based retrospective matched-cohort study.
Article in PeerJ, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 61 papers, 2 of them syntheses that pooled it.
What it found
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
61 citing papers in PubMed, 2 syntheses or guidelines pooled it, 94 citations in OpenAlex.
- Is There an Association Between Parkinson's Disease and Periodontitis? A Systematic Review and Meta-Analysis.Journal of Parkinson's disease · 2023Pooled it
- Oral Microbiota Associated With Parkinson'S Disease: A Systematic Review.Special care in dentistry : official publication of the American Association of Hospital Dentists, the Academy of Dentistry for the Handicapped, and the American Society for Geriatric DentistryPooled it
- Article
- Bioactive peptides in Endodontic infections: The Good, The Bad, and The Ugly.Probiotics and antimicrobial proteins · 2026Review
- Periodontitis and Parkinson's disease: a narrative review of associations, proposed mechanisms, and clinical considerations.Frontiers in oral health · 2026Review
- The oral - X axis: from periodontal dysbiosis to systemic disease.Frontiers in immunology · 2026Review
- Parkinson's disease and Porphyromonas gingivalis levels: a case-control study.Journal of applied oral science : revista FOB · 2026Article
- Effect of natural compounds on NRF2/KEAP1 signaling in periodontitis: a potential use to prevent age-related disorders.Molecular biology reports · 2025Review
- Evaluating dental health in patients with different severity of Parkinson's disease: a cross-sectional study.BMC oral health · 2025Article
- Unraveling brain aging through the lens of oral microbiota.Neural regeneration research · 2025Article
- Research Trends in the Comorbidity Between Periodontitis and Neurodegenerative Diseases.International dental journal · 2025Article
- Relationship between periodontitis and systemic health conditions: a narrative review.Ewha medical journal · 2025Review
- Review
- Kufor-Rakeb Syndrome in a Guatemalan Patient With anCase reports in genetics · 2025Article
- Addressing disparities in oral health access and outcomes for aging adults in the United States.Frontiers in dental medicine · 2025Review
- Oral Microbiota and Porphyromonas gingivalis Kgp Genotypes Altered in Parkinson's Disease with Mild Cognitive Impairment.Molecular neurobiology · 2024Article
- Microbiota Orchestra in Parkinson's Disease: The Nasal and Oral Maestros.Biomedicines · 2024Review
- Balancing the Oral-Gut-Brain Axis with Diet.Nutrients · 2024Review
- Oral Microbiome: A Review of Its Impact on Oral and Systemic Health.Microorganisms · 2024Review
- Potential correlation between chronic periodontitis and Parkinson's disease.Hua xi kou qiang yi xue za zhi = Huaxi kouqiang yixue zazhi = West China journal of stomatology · 2024Article
1 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe cause-effect relation between periodontal inflammatory disease (PID) and Parkinson's disease (PD) remains uncertain. The purpose of our study was to investigate the association between PID and PD.
methodsWe conducted a retrospective matched-cohort study by using Taiwan's National Health Insurance Research Database. We identified 5,396 patients with newly diagnosed PID during 1997-2004 and 10,792 cases without PID by matching sex, age, index of year (occurrence of PID), and comorbidity. Cox proportional hazard regression was used to evaluate the risk of subsequent PD.
resultsAt the final follow-up, a total of 176 (3.26%) and 275 (2.55%) individuals developed PD in the case and control groups, respectively. Patients with PID have a higher risk of developing PD (adjusted hazard ratio = 1.431, 95% CI [1.141-1.794], DISCUSSION: Our results show that PID is associated with an increased risk of developing PD. Whilst these findings suggest that reducing PID may modify the risk of developing PD, further study will be needed.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.