ArticleBrain and behavior2017
Social and environmental enrichment has different effects on ethanol and sucrose consumption in mice.
Article in Brain and behavior, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
31 citing papers in PubMed, 1 synthesis or guideline pooled it, 57 citations in OpenAlex.
- Bored at home?-A systematic review on the effect of environmental enrichment on the welfare of laboratory rats and mice.Frontiers in veterinary science · 2022Pooled it
- Intranasal vasopressin, but not oxytocin, decreases ethanol intake in socially housed mice.Psychopharmacology · 2026Article
- The effects of adolescent social isolation and group housing on adolescent binge drinking in mice.PloS one · 2026Article
- Operant ethanol self-administration behaviors do not predict sex differences in continuous access home cage drinking.Alcohol (Fayetteville, N.Y.) · 2025Article
- A Novel Mouse Home Cage Lickometer System Reveals Sex- and Housing-Based Influences on Alcohol Drinking.eNeuro · 2024Article
- A novel mouse home cage lickometer system reveals sex- and housing-based influences on alcohol drinking.bioRxiv : the preprint server for biology · 2024Article
- Effects of social housing on alcohol intake in mice depend on the non-social environment.Frontiers in behavioral neuroscience · 2024Article
- Retinoic acid modulation of granule cell activity and spatial discrimination in the adult hippocampus.Frontiers in cellular neuroscience · 2024Article
- Experimental Models of Alcohol Use Disorder and Their Application for Pathophysiological Investigations.Current protocols · 2023Article
- Socially Integrated Polysubstance (SIP) system: An open-source solution for continuous monitoring of polysubstance fluid intake in group housed mice.Addiction neuroscience · 2023Article
- IntelliCage: the development and perspectives of a mouse- and user-friendly automated behavioral test system.Frontiers in behavioral neuroscience · 2023Review
- Environmental enrichment improves hippocampus-dependent spatial learning in female C57BL/6 mice in novel IntelliCage sweet reward-based behavioral tests.Frontiers in behavioral neuroscience · 2023Article
- Chemogenetic inhibition of corticotropin-releasing factor neurons in the central amygdala alters binge-like ethanol consumption in male mice.Behavioral neuroscience · 2022Article
- FACTORS CONTRIBUTING TO THE ESCALATION OF ALCOHOL CONSUMPTION.Neuroscience and biobehavioral reviews · 2022Review
- Effects of Social Isolation on the Development of Anxiety and Depression-Like Behavior in Model Experiments in Animals.Neuroscience and behavioral physiology · 2022Article
- Effects of sex and genotype in human APOE-targeted replacement mice on alcohol self-administration measured with the automated IntelliCage system before and after repeated mild traumatic brain injury.Alcoholism, clinical and experimental research · 2021Article
- Ethanol intake in male mice exposed to social defeat: Environmental enrichment potentiates resilience.Neurobiology of stress · 2021Article
- Assessing effects of oxytocin on alcohol consumption in socially housed prairie voles using radio frequency tracking.Addiction biology · 2021Article
- Temporal analysis of individual ethanol consumption in socially housed mice and the effects of oxytocin.Psychopharmacology · 2021Article
- The IntelliCage System: A Review of Its Utility as a Novel Behavioral Platform for a Rodent Model of Substance Use Disorder.Frontiers in behavioral neuroscience · 2021Review
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
Abstract
backgroundFactors leading to the harmful consumption of substances, like alcohol and sucrose, involve a complex interaction of genes and the environment. While we cannot control the genes we inherit, we can modify our environment. Understanding the role that social and environmental experiences play in alcohol and sucrose consumption is critical for developing preventative interventions and treatments for alcohol use disorders and obesity.
methodsWe used the drinking in the dark two-bottle choice (2BC) model of ethanol and sucrose consumption to compare male C57BL/6 mice housed in the IntelliCage (an automated device capable of simultaneously measuring behaviors of up to 16 mice living in an enriched social environment) with mice housed in standard isolated and social environments.
resultsConsistent with previous publications on ethanol-naïve and -experienced mice, social and environmental enrichment reduced ethanol preference. Isolated mice had the highest ethanol preference and IntelliCage mice the least, regardless of prior ethanol experience. In mice with no prior sucrose experience, the addition of social and environmental enrichment increased sucrose preference. However, moving isolated mice to enriched conditions did not affect sucrose preference in sucrose-experienced mice.
conclusionsThe impact of social and environmental enrichment on ethanol consumption differs from sucrose consumption suggesting that interventions and treatments developed for alcohol use disorders may not be suitable for sucrose consumption disorders.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.