ArticleBrain and behavior2017
Cortical thickness and subcortical structure volume abnormalities in patients with major depression with and without anxious symptoms.
Article in Brain and behavior, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 4 of them syntheses that pooled it.
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Who cites it
31 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- Grey matter structural alterations in anxiety disorders: a voxel-based meta-analysis.Brain imaging and behavior · 2024Pooled it
- Shape analysis of subcortical structures in obsessive-compulsive disorder and the relationship with comorbid anxiety, depression, and medication use: A meta-analysis by the OCD Brain Imaging Consortium.Brain and behavior · 2022Pooled it
- Volumetric brain differences in clinical depression in association with anxiety: a systematic review with meta-analysis.Journal of psychiatry & neuroscience : JPN · 2020Pooled it
- Gray Matter Alterations in Parkinson's Disease With Rapid Eye Movement Sleep Behavior Disorder: A Meta-Analysis of Voxel-Based Morphometry Studies.Frontiers in aging neuroscience · 2020Pooled it
- Anxious depression as a clinically relevant subtype of pediatric major depressive disorder.Journal of neural transmission (Vienna, Austria : 1996) · 2019Trial
- Aberrant functional connectivity of the globus pallidus in the modulation of the relationship between childhood trauma and major depressive disorder.Journal of psychiatry & neuroscience : JPNTrial
- Structural Brain Correlates of Childhood Inhibited Temperament: An ENIGMA-Anxiety Mega-Analysis.Journal of the American Academy of Child and Adolescent Psychiatry · 2026Article
- Structural brain alterations in patients with anxious depression: evidence from the REST-meta-MDD project.Frontiers in psychiatry · 2025Article
- Brain structural and functional abnormalities in affective network are associated with anxious depression.BMC psychiatry · 2024Article
- Identifying tripartite relationship among cortical thickness, neuroticism, and mood and anxiety disorders.Scientific reports · 2024Article
- Multiomic approach and Mendelian randomization analysis identify causal associations between blood biomarkers and subcortical brain structure volumes.NeuroImage · 2023Article
- Identification of structural brain alterations in adolescents with depressive symptomatology.Brain research bulletin · 2023Article
- Multiomic approach and Mendelian randomization analysis identify causal associations between blood biomarkers and subcortical brain structure volumes.medRxiv : the preprint server for health sciences · 2023Article
- Plausible Role of Stem Cell Types for Treating and Understanding the Pathophysiology of Depression.Pharmaceutics · 2023Review
- Review
- Reduced cortical surface area globally and in reward-related cortex is associated with elevated depressive symptoms in preschoolers.Journal of affective disorders · 2022Article
- Cortical thickness in parietal regions link perseverative thinking with suicidal ideation.Journal of affective disorders · 2022Article
- Reward-Related Neural Circuitry in Depressed and Anxious Adolescents: A Human Connectome Project.Journal of the American Academy of Child and Adolescent Psychiatry · 2022Article
- Convergence, preliminary findings and future directions across the four human connectome projects investigating mood and anxiety disorders.NeuroImage · 2021Article
- Preliminary Comparison of Subcortical Structures in Elderly Subclinical Depression: Structural Analysis with 3T MRI.Experimental neurobiology · 2021Article
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
backgroundAnxious depression is one of the common subtypes of major depressive disorder (MDD). Clinically, patients with anxious depression exhibit more severe depressive symptoms than patients with nonanxious depression. The aim of the present study was to explore the common and differing cortical and subcortical structural changes between patients with anxious and nonanxious depression.
methodsPatients were placed into one of three groups: the anxious depression group (MDD patients with high levels of anxiety symptoms,
resultsCompared to controls, MDD patients showed thinner cortical thickness in the left inferior temporal, the right superior temporal, and the right parsorbitalis, and a smaller volume of the left hippocampus. Compared to nonanxious depression, anxious depressive patients showed a cortical thinning of the left superior frontal and right superior temporal, as well as the right lingual, and significantly increased subcortical volume of the bilateral caudate nuclei. Correlation analysis showed that the volumes of the bilateral caudate nuclei were directly proportional to the anxiety/somatization factor score.
conclusionsThese findings suggest that smaller hippocampal volume and atrophic prefrontal and temporal cortices might be a common pattern of cortical and subcortical alterations in patients with depression and/or anxiety. However, the change in the caudate nucleus volume may be indicative of anxious depression and may potentially be used to distinguish anxious from nonanxious depression.
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