Observational studyBrain and behavior2017
Can we predict drug response by volumes of the corpus callosum in newly diagnosed focal epilepsy?
Observational study in Brain and behavior, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- Fiber ball white matter modeling in focal epilepsy.Human brain mapping · 2021Article
- Altered structural connectome in non-lesional newly diagnosed focal epilepsy: Relation to pharmacoresistance.NeuroImage. Clinical · 2021Article
- Resting state functional connectivity patterns associated with pharmacological treatment resistance in temporal lobe epilepsy.Epilepsy research · 2019Article
- Resting-state functional brain networks in adults with a new diagnosis of focal epilepsy.Brain and behavior · 2019Article
- Can we predict drug response by volumes of the corpus callosum in newly diagnosed focal epilepsy?Brain and behavior · 2017Observational
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4 authors.
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Abstract
objectiveThe aim of this study was to investigate whether volumes of the corpus callosum could predict a response to antiepileptic drugs in patients with newly diagnosed focal epilepsy.
methodsFifty-three patients with newly diagnosed focal epilepsy of unknown etiology and healthy subjects were enrolled in this study. First, we analyzed the differences in the volumes of the corpus callosum between patients with epilepsy and healthy subjects. Second, we divided patients with epilepsy into antiepileptic drug responders and drug nonresponders groups, according to their seizure controls, and evaluated the differences in the volumes of the corpus callosum between the groups. Third, we conducted correlation analyses between the volumes of the corpus callosum and mean diffusion measures in healthy subjects.
resultsThe volumes of the corpus callosum in patients with epilepsy were significantly lower than those in normal controls (
conclusionsWe demonstrated that the volumes of the corpus callosum were different according to antiepileptic drug responses in patients with newly diagnosed focal epilepsy, which might suggest that the volumes of the corpus callosum could be a new biomarker for predicting responses to antiepileptic drugs.
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