ArticleInternational journal of organ transplantation medicine2017
The Long-term Outcome of Pediatric Kidney Transplantation in Iran: Results of a 25-year Single-Center Cohort Study.
Article in International journal of organ transplantation medicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.
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Who cites it
8 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Is Preemptive Kidney Transplantation Associated With Improved Outcomes when Compared to Non-preemptive Kidney Transplantation in Children? A Systematic Review and Meta-Analysis.Transplant international : official journal of the European Society for Organ Transplantation · 2022Pooled it
- Long-term outcomes and influencing factors following pediatric kidney transplantation: a single-center cohort study from China.Frontiers in pediatrics · 2025Article
- Case report: Challenging kidney transplantation in an adolescent patient with tetralogy of Fallot.Frontiers in medicine · 2024Article
- Graft and Patient Survival Rate among Iranian Pediatric Recipients of Kidney Transplantation: A Systematic Review and Meta-Analysis.Iranian journal of public health · 2022Review
- Paediatric kidney transplantation in under-resourced regions-a panoramic view.Pediatric nephrology (Berlin, Germany) · 2022Review
- Addressing the Ethical Challenges of Providing Kidney Failure Care for Children: A Global Stance.Frontiers in pediatrics · 2022Review
- Characterizing the frequency of modifiable histological changes observed on surveillance biopsies in pediatric kidney allograft recipients.Pediatric nephrology (Berlin, Germany) · 2020Article
- Pediatric Renal Transplantation in Oman: A Single-center Experience.Oman medical journal · 2018Article
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Authors and funding
5 authors.
Funding
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Abstract
backgroundKidney transplantation is the optimal treatment for end-stage renal disease in children. However, long-term graft survival has not significantly improved among pediatric patients.
objectiveTo investigate the determinants of long-term graft survival among Iranian pediatric recipients of kidney transplantation.
methodsIn a single-center cohort study, we studied 314 pediatric kidney transplantations performed from 1989 to 2013 at Dr. Shariati Hospital, Tehran, Iran. Different variables were collected for each patient and graft survival rates were calculated.
resultsAfter a mean±SD follow-up period of 15.8±4.0 years, the mean±SD graft survival rate was 14.5±0.5 years; the 1-, 5-, 10-, and 20-year mean graft survival rates were 90%, 81%, 62%, and 62%, respectively. The corresponding patient survival rates were 100%, 99.4%, 97.8%, and 96.5%, respectively. Pre-emptive transplantation (p=0.006), and living graft donation (p=0.002) led to higher graft survival, while acute rejection (p=0.002), and primary disease of primary hyperoxaluria (p=0.001) led to lower graft survival. Chronic rejection was the most frequent cause of graft loss.
conclusionShort-term graft survival still outpaces the long-term outcome. Modifying the mentioned determinants, with more intense immunosuppression for greater prevention of acute and chronic rejection, and increased rate of pre-emptive transplantation and living donor transplantation, long-term graft survival may significantly improve in future.
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