ArticleJournal of clinical and experimental dentistry2017
Oral manifestations as the first presenting sign of Crohn's disease in a pediatric patient.
Article in Journal of clinical and experimental dentistry, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
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The trial behind it
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Who cites it
11 citing papers in PubMed, 24 citations in OpenAlex.
- The oral - X axis: from periodontal dysbiosis to systemic disease.Frontiers in immunology · 2026Review
- Unravelling the Oral-Gut Axis: Interconnection Between Periodontitis and Inflammatory Bowel Disease, Current Challenges, and Future Perspective.Journal of Crohn's & colitis · 2024Review
- Oral Manifestations of Crohn's Disease: A Systematic Review.Journal of clinical medicine · 2023Review
- Oral Microbiome of Crohn's Disease Patients With and Without Oral Manifestations.Journal of Crohn's & colitis · 2022Article
- Non-infectious granulomatous disorders of the upper lip: clinicopathological analysis of 11 patients.BMC oral health · 2022Article
- Comprehensive management of major aphthous ulcer.BMJ case reports · 2021Article
- Oral and Maxillo-Facial Manifestations of Systemic Diseases: An Overview.Medicina (Kaunas, Lithuania) · 2021Review
- The "Gum-Gut" Axis in Inflammatory Bowel Diseases: A Hypothesis-Driven Review of Associations and Advances.Frontiers in immunology · 2021Review
- A rare case of pediatric Crohn's disease and alveolar bone loss: a report and review.Translational pediatrics · 2020Article
- Non-infectious Granulomatous Lesions of the Orofacial Region.Head and neck pathology · 2019Review
- Th17 Cells and the IL-23/IL-17 Axis in the Pathogenesis of Periodontitis and Immune-Mediated Inflammatory Diseases.International journal of molecular sciences · 2019Review
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Crohn's disease (CD) is a chronic inflammatory disorder affecting the gastrointestinal (GI) tract. Although the GI tract is the primary site of involvement, many patients, particularly in pediatric cases, first present with non-intestinal manifestations, including oral lesions. Oral manifestations of CD in children occur in around 50-80% of cases, and about 30% of CD cases in children occur first in the mouth. Recognizing such oral lesions in the pediatric population, and requesting a biopsy, may expedite the diagnosis of CD. We describe a 15 year old male who presented with oral findings of multiple aphthous ulcers and plaques of pink papules of the buccal vestibule. We highlight the initial pathology findings, including non-caseating granulomas, sialadenitis, and a notable plasmacytosis, from biopsy of the left retromolar pad area, which triggered further testing for CD. We provide discussion of how CD was eventually diagnosed and treated and highlight the significance of the pathological findings in this case as they relate to the pathogenesis of CD.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.