ArticlePloS one2017
Role of atrial wall thickness in wave-dynamics of atrial fibrillation.
Article in PloS one, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- Structural determinants of re-entrant drivers in atrial fibrillation: insights from digital twins derived from 3D micrometre-resolution imaging of human heart.The Journal of physiology · 2026Article
- Electrical gaps in recurrence of atrial tachyarrhythmias after Maze surgery: regional patterns and clinical significance.Nagoya journal of medical science · 2025Article
- Identification of left atrial wall thickness in substrate mapping of atrial fibrillation.Frontiers in cardiovascular medicine · 2025Article
- Increased body mass index, age, and left atrial size are associated with altered intracardiac atrial electrograms in persistent atrial fibrillation patients.Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing · 2021Article
- In situ procedure for high-efficiency computational modeling of atrial fibrillation reflecting personal anatomy, fiber orientation, fibrosis, and electrophysiology.Scientific reports · 2020Article
- A robust computational framework for estimating 3D Bi-Atrial chamber wall thickness.Computers in biology and medicine · 2019Article
- Addressing challenges of quantitative methodologies and event interpretation in the study of atrial fibrillation.Computer methods and programs in biomedicine · 2019Review
- Entropy Mapping Approach for Functional Reentry Detection in Atrial Fibrillation: An In-Silico Study.Entropy (Basel, Switzerland) · 2019Article
- VirtualFrontiers in physiology · 2017Article
- State of the art paper: Cardiac computed tomography of the left atrium in atrial fibrillation.Journal of cardiovascular computed tomographyReview
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Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND/
aimsAtrial anatomy and thickness may affect the electrical wave-dynamics of atrial fibrillation (AF). We explored the relationship between left atrial (LA) wall thickness (LAWT) or LA geometry and AF wave-dynamics.
methodsWe included 15 patients with persistent AF (age, 62.3 ± 11.9 years) who underwent AF catheter ablation. We measured the LAWT, LA endocardial curvature, and SD-curvature (surface bumpiness) from preprocedural computed tomography images. We compared those anatomical characteristics with electrophysiologic parameters such as dominant frequency (DF), Shannon entropy (ShEn), or complex fractionated atrial electrogram (CFAE)-cycle length (CL), calculated from intracardiac bipolar electrograms (300-500 points, 5 s), acquired during ablation procedures.
results1. LAWT (excluding fat) varied widely among patients, locations, and types of AF. LAWT was inversely correlated with LA volume (r = -0.565, p = 0.028) and positively correlated with SD-curvature (r = 0.272, p < 0.001). 2. LAWT was positively correlated with ShEn (r = 0.233, p < 0.001) and negatively correlated with CFAE-CL (r = -0.107, p = 0.038). 3. In the multivariate linear regression analyses for AF wave-dynamics parameters, DF (β = -0.29 [95% CI -0.44--0.14], p < 0.001), ShEn (β = 0.19 [95% CI 0.12-0.25], p < 0.001), and CFAE-CL (β = 7.49 [95% CI 0.65-14.34], p = 0.032) were independently associated with LAWT.
conclusionRegional LAWT is associated with LA structural features, and has significant correlations with the wave-dynamics parameters associated with electrical wavebreaks or rotors in patients with persistent AF.
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