ArticleScientific reports2017
Evolutionary shifts in gene expression decoupled from gene duplication across functionally distinct spider silk glands.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 40 citations in OpenAlex.
- Evolution of Highly Repetitive Silk Genes in the Luna Moth, Actias luna.Genome biology and evolution · 2026Article
- A newly evolved small secretory peptide enhances mechanical properties of spider silk.Nature communications · 2025Article
- Origin, structure, and composition of the spider major ampullate silk fiber revealed by genomics, proteomics, and single-cell and spatial transcriptomics.Science advances · 2024Article
- From fibres to adhesives: evolution of spider capture threads from web anchors by radical changes in silk gland function.Journal of the Royal Society, Interface · 2024Article
- Spinneret spinning field ontogeny and life history observations in the spiderThe Journal of arachnology · 2024Article
- Molecular mechanisms of the high performance of spider silks revealed through multi-omics analysis.Biophysics and physicobiology · 2023Article
- The evolutionary history of cribellate orb-weaver capture thread spidroins.BMC ecology and evolution · 2022Article
- Complexity of Spider Dragline Silk.Biomacromolecules · 2022Review
- Evolution of Gene Expression across Species and Specialized Zooids in Siphonophora.Molecular biology and evolution · 2022Article
- Protein Composition and Associated Material Properties of Cobweb Spiders' Gumfoot Glue Droplets.Integrative and comparative biology · 2021Article
- Critical role of minor eggcase silk component in promoting spidroin chain alignment and strong fiber formation.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Egg Case Protein 3: A Constituent of Black Widow Spider Tubuliform Silk.Molecules (Basel, Switzerland) · 2021Article
- Shifts in morphology, gene expression, and selection underlie web loss in Hawaiian Tetragnatha spiders.BMC ecology and evolution · 2021Article
- Golden orb-weaving spider (Trichonephila clavipes) silk genes with sex-biased expression and atypical architectures.G3 (Bethesda, Md.) · 2021Article
- Spider phylosymbiosis: divergence of widow spider species and their tissues' microbiomes.BMC evolutionary biology · 2020Article
- Structural Characterization of Black Widow Spider Dragline Silk Proteins CRP1 and CRP4.Molecules (Basel, Switzerland) · 2020Article
- Ovarian Transcriptomic Analyses in the Urban Human Health Pest, the Western Black Widow Spider.Genes · 2020Article
- The common house spider, Parasteatoda tepidariorum, maintains silk gene expression on sub-optimal diet.PloS one · 2020Article
- Orb-weaving spider Araneus ventricosus genome elucidates the spidroin gene catalogue.Scientific reports · 2019Article
- Toward Spider Glue: Long Read Scaffolding for Extreme Length and Repetitious Silk Family Genes AgSp1 and AgSp2 with Insights into Functional Adaptation.G3 (Bethesda, Md.) · 2019Article
Corrections and comments
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Authors and funding
6 authors at 4 institutions in 1 country.
Funding
Abstract
Spider silk synthesis is an emerging model for the evolution of tissue-specific gene expression and the role of gene duplication in functional novelty, but its potential has not been fully realized. Accordingly, we quantified transcript (mRNA) abundance in seven silk gland types and three non-silk gland tissues for three cobweb-weaving spider species. Evolutionary analyses based on expression levels of thousands of homologous transcripts and phylogenetic reconstruction of 605 gene families demonstrated conservation of expression for each gland type among species. Despite serial homology of all silk glands, the expression profiles of the glue-forming aggregate glands were divergent from fiber-forming glands. Also surprising was our finding that shifts in gene expression among silk gland types were not necessarily coupled with gene duplication, even though silk-specific genes belong to multi-paralog gene families. Our results challenge widely accepted models of tissue specialization and significantly advance efforts to replicate silk-based high-performance biomaterials.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.