ArticleScientific reports2017
A model for relative biological effectiveness of therapeutic proton beams based on a global fit of cell survival data.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.
What it found
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Who cites it
12 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Risk of Cerebrovascular Events Among Childhood and Adolescent Patients Receiving Cranial Radiation Therapy: A PENTEC Normal Tissue Outcomes Comprehensive Review.International journal of radiation oncology, biology, physics · 2024Pooled it
- Neural network modelling of proton RBE values at predominant survival fractions of in vitro data.Scientific reports · 2026Article
- Monte Carlo calculations of target fragments from helium and carbon ion interactions with water.Zeitschrift fur medizinische Physik · 2026Article
- 'Dirty dose'-based proton variable RBE models - performance assessment on in vitro data.Medical physics · 2025Article
- Report on G4-Med, a Geant4 benchmarking system for medical physics applications developed by the Geant4 Medical Simulation Benchmarking Group.Medical physics · 2021Article
- A new approach to modeling the microdosimetry of proton therapy beams.Medical physics · 2020Article
- A DNA damage multiscale model for NTCP in proton and hadron therapy.Medical physics · 2020Article
- Using the Proton Energy Spectrum and Microdosimetry to Model Proton Relative Biological Effectiveness.International journal of radiation oncology, biology, physics · 2019Article
- Increased risk of pseudoprogression among pediatric low-grade glioma patients treated with proton versus photon radiotherapy.Neuro-oncology · 2019Article
- Renormalization of radiobiological response functions by energy loss fluctuations and complexities in chromosome aberration induction: deactivation theory for proton therapy from cells to tumor control.The European physical journal. D, Atomic, molecular, and optical physics · 2019Article
- Modelling of Cellular Survival Following Radiation-Induced DNA Double-Strand Breaks.Scientific reports · 2018Article
- Proton Relative Biological Effectiveness - Uncertainties and Opportunities.International journal of particle therapy · 2018Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
We introduce an approach for global fitting of the recently published high-throughput and high accuracy clonogenic cell-survival data for therapeutic scanned proton beams. Our fitting procedure accounts for the correlation between the cell-survival, the absorbed (physical) dose and the proton linear energy transfer (LET). The fitting polynomials and constraints have been constructed upon generalization of the microdosimetric kinetic model (gMKM) adapted to account for the low energy and high lineal-energy spectrum of the beam where the current radiobiological models may underestimate the reported relative biological effectiveness (RBE). The parameters (α, β) of the linear-quadratic (LQ) model calculated by the presented method reveal a smooth transition from low to high LETs which is an advantage of the current method over methods previously employed to fit the same clonogenic data. Finally, the presented approach provides insight into underlying microscopic mechanisms which, with future study, may help to elucidate radiobiological responses along the Bragg curve and resolve discrepancies between experimental data and current RBE models.
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