Evidence map›Paper›PMID 28827674›Full record

ArticleScientific reports2017

Analyses in zebrafish embryos reveal that nanotoxicity profiles are dependent on surface-functionalization controlled penetrance of biological membranes.

Ilkka Paatero, Eudald Casals, Rasmus Niemi, Ezgi Özliseli, Jessica M Rosenholm, Cecilia Sahlgren

Abstract read
In one paragraph

Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed.

  1. Review
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  8. Toxicity evaluation of silica nanoparticles for delivery applications.Drug delivery and translational research · 2023
    Review
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Review
  16. Article
  17. Article
  18. Exploring the mechanisms of graphene oxide behavioral and morphological changes in zebrafish.Environmental science and pollution research international · 2019
    Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Ilkka PaateroDepartment of Cell Biology, Biozentrum, University of Basel, Basel, Switzerland. ilkka.paatero@utu.fi.
Eudald CasalsPharmaceutical Sciences Laboratory, Faculty of Science and Engineering, Åbo Akademi University, FI-20520, Turku, Finland.
Rasmus NiemiFaculty of Science and Engineering, Cell Biology, Åbo Akademi University, FI-20520, Turku, Finland.
Ezgi ÖzliseliPharmaceutical Sciences Laboratory, Faculty of Science and Engineering, Åbo Akademi University, FI-20520, Turku, Finland.
Jessica M RosenholmPharmaceutical Sciences Laboratory, Faculty of Science and Engineering, Åbo Akademi University, FI-20520, Turku, Finland.ORCID 0000-0001-6085-1112
Cecilia SahlgrenFaculty of Science and Engineering, Cell Biology, Åbo Akademi University, FI-20520, Turku, Finland. cecilia.sahlgren@abo.fi.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Mesoporous silica nanoparticles (MSNs) are extensively explored as drug delivery systems, but in depth understanding of design-toxicity relationships is still scarce. We used zebrafish (Danio rerio) embryos to study toxicity profiles of differently surface functionalized MSNs. Embryos with the chorion membrane intact, or dechoroniated embryos, were incubated or microinjected with amino (NH

Indexed as

NanoparticlesPermeabilitySurface PropertiesAnimalsCalcium CompoundsCardiovascular SystemEmbryo, NonmammalianMembranesSilicatesSurvival AnalysisZebrafishCalcium Compoundscalcium silicateSilicates

Identifiers

PMID28827674
PMCPMC5566213

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.