Evidence map›Paper›PMID 28827668›Full record

ArticleScientific reports2017

A clue to unprecedented strategy to HIV eradication: "Lock-in and apoptosis".

Hiroshi Tateishi, Kazuaki Monde, Kensaku Anraku, Ryoko Koga, Yuya Hayashi, Halil Ibrahim Ciftci, Hasan DeMirci, Taishi Higashi, Keiichi Motoyama, Hidetoshi Arima and 2 more

Abstract read
In one paragraph

Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Article
  6. A New Series of Indeno[1,2-Molecules (Basel, Switzerland) · 2022
    Article
  7. Article
  8. EGFR-Targeted Pentacyclic Triterpene Analogues for Glioma Therapy.International journal of molecular sciences · 2021
    Article
  9. Article
  10. Review
  11. Article
  12. Review
  13. Article
  14. Effects of Glycyrrhetic Acid on Human Chronic Myelogenous Leukemia Cells.Turkish journal of pharmaceutical sciences · 2020
    Article
  15. Measuring the Success of HIV-1 Cure Strategies.Frontiers in cellular and infection microbiology · 2020
    Review
  16. Article
  17. Article
  18. Review
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Hiroshi Tateishi
Kazuaki MondeDepartment of Microbiology, Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan.ORCID 0000-0002-8314-5306
Kensaku AnrakuDepartment of Medical Technology, Kumamoto Health Science University, Kumamoto, Japan.
Ryoko KogaDepartment of Bioorganic Medicinal Chemistry, Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan.
Yuya HayashiDepartment of Physical Pharmaceutics, Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan.
Halil Ibrahim CiftciDepartment of Bioorganic Medicinal Chemistry, Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan.
Hasan DeMirciStanford PULSE Institute, SLAC National Accelerator Laboratory, Menlo Park, California, USA.ORCID 0000-0002-9135-5397
Taishi HigashiDepartment of Physical Pharmaceutics, Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan.
Keiichi MotoyamaDepartment of Physical Pharmaceutics, Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan.
Hidetoshi ArimaDepartment of Physical Pharmaceutics, Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan.
Masami OtsukaDepartment of Bioorganic Medicinal Chemistry, Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan. motsuka@gpo.kumamoto-u.ac.jp.
Mikako FujitaResearch Institute for Drug Discovery, School of Pharmacy, Kumamoto University, Kumamoto, Japan. mfujita@kumamoto-u.ac.jp.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Despite the development of antiretroviral therapy against HIV, eradication of the virus from the body, as a means to a cure, remains in progress. A "kick and kill" strategy proposes "kick" of the latent HIV to an active HIV to eventually be "killed". Latency-reverting agents that can perform the "kick" function are under development and have shown promise. Management of the infected cells not to produce virions after the "kick" step is important to this strategy. Here we show that a newly synthesized compound, L-HIPPO, captures the HIV-1 protein Pr55

Indexed as

Anti-HIV AgentsCell MembraneCell SurvivalCytoplasmDisease EradicationHeLa CellsHIV-1HIV InfectionsHumansInositol PhosphatesJurkat CellsMolecular StructureProtein PrecursorsSmall Molecule LibrariesStereoisomerismVirus ActivationAnti-HIV AgentsInositol Phosphatesp55 gag precursor protein, Human immunodeficiency virus 1Protein PrecursorsSmall Molecule Libraries

Identifiers

PMID28827668
PMCPMC5567282

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.