ArticleScientific reports2017
Peptide biomarkers used for the selective breeding of a complex polygenic trait in honey bees.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed.
- Reconsidering the Selection Strategy in a Flemish Honey Bee Breeding Program: Towards Selection by Exclusion.Insects · 2026Article
- Body Size and Body Weight inLife (Basel, Switzerland) · 2026Article
- Biological costs and benefits of selective breeding for disease resistance using marker-assisted or field-based selective breeding in honey bees (Apis mellifera).Journal of economic entomology · 2026Article
- Pheromone and morphometric features of honey bee (Apis mellifera) queens imported to Canada from around the globe.PloS one · 2026Article
- AI-enhanced marker-assisted selection concept for the multifunctional honey bee (Hymenoptera: Apidea) protein Vitellogenin (Vg).Journal of economic entomology · 2025Article
- Article
- Article
- Sequence-Based Multi Ancestry Association Study Reveals the Polygenic Architecture of Varroa destructor Resistance in the Honeybee Apis mellifera.Molecular ecology · 2025Article
- Review
- Heightened sensitivity in high-grooming honey bees (Hymenoptera: Apidae).Journal of insect science (Online) · 2024Article
- Emerging threats and opportunities to managed bee species in European agricultural systems: a horizon scan.Scientific reports · 2023Article
- Expression of Molecular Markers of Resilience againstInsects · 2023Article
- Phenotypic and genetic characterization of AfricanizedFrontiers in insect science · 2023Article
- Whole genome resequencing reveals signatures of rapid selection in a virus-affected commercial fishery.Molecular ecology · 2022Article
- A derived honey bee stock confers resistance to Varroa destructor and associated viral transmission.Scientific reports · 2022Article
- Phenomic analysis of the honey bee pathogen-web and its dynamics on colony productivity, health and social immunity behaviors.PloS one · 2022Article
- Impacts of COVID-19 on Canadian Beekeeping: Survey Results and a Profitability Analysis.Journal of economic entomology · 2021Article
- qPCR assays with dual-labeled probes for genotyping honey bee variants associated with varroa resistance.BMC veterinary research · 2021Article
- Article
- Advances and perspectives in selecting resistance traits against the parasitic mite Varroa destructor in honey bees.Genetics, selection, evolution : GSE · 2020Review
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Authors and funding
17 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We present a novel way to select for highly polygenic traits. For millennia, humans have used observable phenotypes to selectively breed stronger or more productive livestock and crops. Selection on genotype, using single-nucleotide polymorphisms (SNPs) and genome profiling, is also now applied broadly in livestock breeding programs; however, selection on protein/peptide or mRNA expression markers has not yet been proven useful. Here we demonstrate the utility of protein markers to select for disease-resistant hygienic behavior in the European honey bee (Apis mellifera L.). Robust, mechanistically-linked protein expression markers, by integrating cis- and trans- effects from many genomic loci, may overcome limitations of genomic markers to allow for selection. After three generations of selection, the resulting marker-selected stock outperformed an unselected benchmark stock in terms of hygienic behavior, and had improved survival when challenged with a bacterial disease or a parasitic mite, similar to bees selected using a phenotype-based assessment for this trait. This is the first demonstration of the efficacy of protein markers for industrial selective breeding in any agricultural species, plant or animal.
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