ArticleScientific reports2017
Lignin Valorization: Two Hybrid Biochemical Routes for the Conversion of Polymeric Lignin into Value-added Chemicals.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
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Who cites it
37 citing papers in PubMed, 159 citations in OpenAlex.
- Engineered Accumulation of Protocatechuate in Corn Biomass to Enhance Biomanufacturing.ACS sustainable chemistry & engineering · 2025Article
- Lignin-Derived Oligomers as Promising mTOR Inhibitors: Insights from Dynamics Simulations.International journal of molecular sciences · 2025Article
- Unlocking lignin valorization and harnessing lignin-based raw materials for bio-manufacturing.Science China. Life sciences · 2025Review
- Engineering yeast to produce fraxetin from ferulic acid and lignin.Applied microbiology and biotechnology · 2025Article
- Aromatic Polymethacrylates from Lignin-Based Feedstock: Synthesis, Thermal Properties, Life-Cycle Assessment and Toxicity.ChemSusChem · 2025Article
- Benzenoid Aromatics from Renewable Resources.Chemical reviews · 2024Review
- Building the bioeconomy: A targeted assessment approach to identifying biobased technologies, challenges and opportunities.Engineering biology · 2024Article
- EngineeringApplied and environmental microbiology · 2024Article
- Microbial Upcycling of Depolymerized Lignin into Value-Added Chemicals.Biodesign research · 2024Article
- Functional Analysis of a Salicylate Hydroxylase inJournal of fungi (Basel, Switzerland) · 2023Article
- Exoproteomic Study and Transcriptional Responses of Laccase and Ligninolytic Peroxidase Genes of White-Rot FungusInternational journal of molecular sciences · 2023Article
- Development and Application of Whole-Cell Biosensors for the Detection of Gallic Acid.ACS synthetic biology · 2023Article
- Valorization of Hemp-Based Packaging Waste with One-Pot Ionic Liquid Technology.Molecules (Basel, Switzerland) · 2023Article
- A new approach to zip-lignin: 3,4-dihydroxybenzoate is compatible with lignification.The New phytologist · 2022Article
- Synthesis and Antibacterial Properties of Oligomeric Dehydrogenation Polymer from Lignin Precursors.Molecules (Basel, Switzerland) · 2022Article
- Progress and challenges in sorghum biotechnology, a multipurpose feedstock for the bioeconomy.Journal of experimental botany · 2022Review
- Article
- Endophytes in Lignin Valorization: A Novel Approach.Frontiers in bioengineering and biotechnology · 2022Review
- Microbial detoxification of lignocellulosic biomass hydrolysates: Biochemical and molecular aspects, challenges, exploits and future perspectives.Frontiers in bioengineering and biotechnology · 2022Review
- A Review on the Utilization of Lignin as a Fermentation Substrate to Produce Lignin-Modifying Enzymes and Other Value-Added Products.Molecules (Basel, Switzerland) · 2021Review
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Naturally, many aerobic organisms degrade lignin-derived aromatics through conserved intermediates including protocatechuate and catechol. Employing this microbial approach offers a potential solution for valorizing lignin into valuable chemicals for a potential lignocellulosic biorefinery and enabling bioeconomy. In this study, two hybrid biochemical routes combining lignin chemical depolymerization, plant metabolic engineering, and synthetic pathway reconstruction were demonstrated for valorizing lignin into value-added products. In the biochemical route 1, alkali lignin was chemically depolymerized into vanillin and syringate as major products, which were further bio-converted into cis, cis-muconic acid (ccMA) and pyrogallol, respectively, using engineered Escherichia coli strains. In the second biochemical route, the shikimate pathway of Tobacco plant was engineered to accumulate protocatechuate (PCA) as a soluble intermediate compound. The PCA extracted from the engineered Tobacco was further converted into ccMA using the engineered E. coli strain. This study reports a direct process for converting lignin into ccMA and pyrogallol as value-added chemicals, and more importantly demonstrates benign methods for valorization of polymeric lignin that is inherently heterogeneous and recalcitrant. Our approach also validates the promising combination of plant engineering with microbial chassis development for the production of value added and speciality chemicals.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.