Evidence map›Paper›PMID 28827563›Full record

ArticleLeukemia2018

RNA interference efficiently targets human leukemia driven by a fusion oncogene in vivo.

N Jyotsana, A Sharma, A Chaturvedi, M Scherr, F Kuchenbauer, L Sajti, A Barchanski, R Lindner, F Noyan, K-W Sühs and 13 more

Abstract readLetter
PubMed Full text at PMC Publisher
In one paragraph

Article in Leukemia, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

23 authors.

N JyotsanaDepartment of Hematology, Hemostasis, Oncology and Stem cell Transplantation, Hannover Medical School, Hannover, Germany.
A SharmaDepartment of Hematology, Hemostasis, Oncology and Stem cell Transplantation, Hannover Medical School, Hannover, Germany.
A ChaturvediDepartment of Hematology, Hemostasis, Oncology and Stem cell Transplantation, Hannover Medical School, Hannover, Germany.
M ScherrDepartment of Hematology, Hemostasis, Oncology and Stem cell Transplantation, Hannover Medical School, Hannover, Germany.
F KuchenbauerDepartment of Internal Medicine III, University Hospital of Ulm, Ulm, Germany.
L SajtiNanotechnology Department, Laser Zentrum Hannover, Hannover, Germany.
A BarchanskiNanotechnology Department, Laser Zentrum Hannover, Hannover, Germany.
R LindnerDepartment of Cell Biology, Center of Anatomy, Hannover Medical School, Hannover, Germany.
F NoyanDepartment of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School, Hannover, Germany.
K-W SühsClinic for Neurology, Hannover Medical School, Hannover, Germany.
D Grote-KoskaDepartment of Clinical Chemistry, Hannover Medical School, Hannover, Germany.
K BrandDepartment of Clinical Chemistry, Hannover Medical School, Hannover, Germany.
H-P VornlocherAxolabs GmBH, Kulmbach, Germany.
M StanullaPediatric Hematology and Oncology, Hannover Medical School, Hannover, Germany.
B BornhauserDepartment of Oncology and Children's Research Centre, University Children's Hospital Zürich, Zürich, Switzerland.
J-P BourquinDepartment of Oncology and Children's Research Centre, University Children's Hospital Zürich, Zürich, Switzerland.
M EderDepartment of Hematology, Hemostasis, Oncology and Stem cell Transplantation, Hannover Medical School, Hannover, Germany.
F TholDepartment of Hematology, Hemostasis, Oncology and Stem cell Transplantation, Hannover Medical School, Hannover, Germany.
A GanserDepartment of Hematology, Hemostasis, Oncology and Stem cell Transplantation, Hannover Medical School, Hannover, Germany.
R K HumphriesTerry Fox Laboratory, British Columbia Cancer Agency, Vancouver, British Columbia, Canada.
E RamsayPrecision NanoSystems, Inc., Vancouver, British Columbia, Canada.
P CullisDepartment of Biochemistry and Molecular Biology, University of British Columbia, Health Sciences Mall, Vancouver, British Columbia, Canada.
M HeuserDepartment of Hematology, Hemostasis, Oncology and Stem cell Transplantation, Hannover Medical School, Hannover, Germany.

Funding

European Research Council 638035
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Amyloid Neuropathies, FamilialAnimalsB-LymphocytesHumansLeukemia, B-CellMiceOncogene Proteins, FusionPrecursor Cell Lymphoblastic Leukemia-LymphomaRNA InterferenceOncogene Proteins, Fusion

Identifiers

PMID28827563
PMCPMC5702262

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.