ArticleJournal of pathology and translational medicine2017
Intraosseous Hibernoma: A Rare and Unique Intraosseous Lesion.
Article in Journal of pathology and translational medicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
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Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it, 25 citations in OpenAlex.
- Clinical, Radiological, and Pathological Features of Intraosseous Hibernoma: A Systematic Review of Case Reports and Case Series.Current oncology (Toronto, Ont.) · 2025Pooled it
- Test yourself answer: 38-year-old female with left hip pain.Skeletal radiology · 2026Article
- Intraosseous hibernoma mimicking sclerotic bone metastasis-a case report.Skeletal radiology · 2025Article
- Intraosseous Lipoma of the Maxillary Sinus: First Documented Case in an Asian Patient and Review of the Literature.Case reports in dentistry · 2025Article
- Femoral hibernoma: unique intraosseous tumor.Wiener klinische Wochenschrift · 2024Article
- Unusual Imaging Findings of Epithelioid Hemangioma: Case Report of Single Intramedullary Sclerotic Bone Lesion.Journal of the Korean Society of Radiology · 2024Article
- A Rare Case of Large Lateral Chest Wall Hibernoma.Cureus · 2024Article
- Intraosseous Hibernoma: A Rare Entity in Orthopedics With Peculiar Radiological Features.Cureus · 2023Article
- Benign incidental do-not-touch bone lesions.The British journal of radiology · 2023Review
- Intraosseous hibernoma: Two case reports and a review of the literature.Radiology case reports · 2022Article
- Intraosseous hibernoma of the appendicular skeleton.Skeletal radiology · 2022Article
- Diagnosis of Intraosseous Hibernoma of an Appendicular Skeleton in an Adult - A Rare Case Report.Journal of orthopaedic case reports · 2022Article
- Intraosseous hibernoma: A metastatic mimicker to consider on the differential.Radiology case reports · 2020Article
- Spinal Intraosseous Hibernoma: A Case Report and Review of Literature.Taehan Yongsang Uihakhoe chi · 2020Article
- A Diagnostic Dilemma of a Subcutaneous Hibernoma: Case Report.The American journal of case reports · 2020Article
- Hibernoma Mimicking Atypical Lipomatous Tumor: 64 Cases of a Morphologically Distinct Subset.The American journal of surgical pathology · 2018Article
- Primary extradural tumors of the spinal column: A comprehensive treatment guide for the spine surgeon based on the 5Journal of craniovertebral junction & spineReview
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundHibernoma is a rare benign tumor of adults that is composed of multivacuolated adipocytes resembling brown fat cells. Hibernoma typically occurs in soft tissue, and intraosseous examples are very rare. Intraosseous hibernomas can radiologically mimic metastatic carcinoma and other tumorous conditions.
methodsTo collect the intraosseous hibernomas, we searched the pathologic database and reviewed the hematoxylin and eosin (H&E)-stained slides of bone biopsy samples performed to differentiate radiologically abnormal bone lesions from 2006 to 2016. A total of six intraosseous hibernoma cases were collected, and clinical and radiological information was verified from electronic medical records. H&E slide review and immunohistochemical staining for CD68, pan-cytokeratin, and S-100 protein were performed.
resultsMagnetic resonance imaging of intraosseous hibernomas showed low signal intensity with slightly hyperintense foci on T1 and intermediate to high signal intensity on T2 weighted images. Intraosseous hibernomas appeared as heterogeneous sclerotic lesions with trabecular thickening on computed tomography scans and revealed mild hypermetabolism on positron emission tomography scans. Histopathologically, the bone marrow space was replaced by sheets of multivacuolated, foamy adipocytes resembling brown fat cells, without destruction of bone trabeculae. In immunohistochemical analysis, the tumor cells were negative for CD68 and pan-cytokeratin and positive for S-100 protein.
conclusionsIntraosseous hibernoma is very rare. This tumor can be overlooked due to its rarity and resemblance to bone marrow fat. Pathologists need to be aware of this entity to avoid misdiagnosis of this rare lesion.
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