Evidence map›Paper›PMID 28827411›Full record

Trial reportBlood2017

Ruxolitinib for essential thrombocythemia refractory to or intolerant of hydroxyurea: long-term phase 2 study results.

Srdan Verstovsek, Francesco Passamonti, Alessandro Rambaldi, Giovanni Barosi, Elisa Rumi, Elisabetta Gattoni, Lisa Pieri, Huiling Zhen, Muriel Granier, Albert Assad and 4 more

Open access · bronzeAbstract readClinical Trial, Phase IILetter
In one paragraph

Trial report in Blood, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed, 1 pooled it
6.3field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed, 1 synthesis or guideline pooled it, 65 citations in OpenAlex.

  1. Guideline
  2. Trial
  3. Review
  4. Article
  5. Article
  6. Review
  7. Article
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  12. Review
  13. Emerging Therapeutic Options for Chronic Pruritus.American journal of clinical dermatology · 2020
    Review
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  15. Review
  16. Review
  17. Review
  18. Review
  19. The Rationale for Immunotherapy in Myeloproliferative Neoplasms.Current hematologic malignancy reports · 2019
    Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 8 institutions in 2 countries.

Srdan VerstovsekDepartment of Leukemia, MD Anderson Cancer Center, University of Texas, Houston, TX.
Francesco PassamontiDepartment of Medicine and Surgery, University of Insubria, Varese, Italy.
Alessandro RambaldiHematology and Bone Marrow Transplant Unit, Azienda Ospedaliera Papa Giovanni XXII, Bergamo, Italy.
Giovanni BarosiCenter for the Study of Myelofibrosis, Fondazione Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) Policlinico San Matteo Foundation, Pavia, Italy.
Elisa RumiDepartment of Molecular Medicine, University of Pavia, Pavia, Italy.
Elisabetta GattoniDepartment of Oncology, Ospedale Santo Spirito, Casale Monferrato, Italy.
Lisa PieriCenter of Research and Innovation of Myeloproliferative Neoplasms, Azienda Ospedaliera Universitaria Careggi, Florence, Italy.
Huiling ZhenIncyte Corporation, Wilmington, DE; and.
Muriel GranierIncyte Corporation, Wilmington, DE; and.
Albert AssadIncyte Corporation, Wilmington, DE; and.
Mario CazzolaDepartment of Molecular Medicine, University of Pavia, Pavia, Italy.
Hagop M KantarjianDepartment of Leukemia, MD Anderson Cancer Center, University of Texas, Houston, TX.
Tiziano BarbuiClinical Research Foundation (FROM), Ospedale Papa Giovanni XXIII, Bergamo, Italy.
Alessandro M VannucchiCenter of Research and Innovation of Myeloproliferative Neoplasms, Azienda Ospedaliera Universitaria Careggi, Florence, Italy.
Incyte (United States) · USIstituti di Ricovero e Cura a Carattere Scientifico · ITOspedale Papa Giovanni XXIII · ITThe University of Texas MD Anderson Cancer Center · USAzienda Ospedaliero-Universitaria Careggi · ITOspedale di Santo Spirito · ITUniversity of Florence · ITUniversity of Insubria · IT

Funding

Tumor Evolution and Metastasis ProgramP30CA016672 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI Scott Kopetz · 1985 to 2026
$290.8M
NCI NIH HHS P30 CA016672
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

AdultAgedHemoglobinsHumansHydroxyureaLeukocyte CountLongitudinal StudiesMiddle AgedNitrilesPlatelet CountPyrazolesPyrimidinesSalvage TherapyThrombocythemia, EssentialHemoglobinsHydroxyureaNitrilesPyrazolesPyrimidinesruxolitinib

Identifiers

PMID28827411
PMCPMC5639482
OpenAlexW2749657249

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.