Evidence map›Paper›PMID 28827398›Full record

ArticleMolecular systems biology2017

Network analyses identify liver-specific targets for treating liver diseases.

Sunjae Lee, Cheng Zhang, Zhengtao Liu, Martina Klevstig, Bani Mukhopadhyay, Mattias Bergentall, Resat Cinar, Marcus Ståhlman, Natasha Sikanic, Joshua K Park and 14 more

Open access · goldAbstract read
In one paragraph

Article in Molecular systems biology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 72 papers.

0numbers the graph read from it
0cells of the map it votes in
72citing papers in PubMed
6.0field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

72 citing papers in PubMed, 117 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Review
  7. Longitudinal big biological data in the AI era.Molecular systems biology · 2025
    Review
  8. Article
  9. Article
  10. Genome-scale models in human metabologenomics.Nature reviews. Genetics · 2025
    Review
  11. Review
  12. Article
  13. Review
  14. Article
  15. Characterization of aniScience · 2023
    Article
  16. Article
  17. Review
  18. Article
  19. Article
  20. Article

12 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

24 authors at 6 institutions in 2 countries.

Sunjae LeeScience for Life Laboratory, KTH - Royal Institute of Technology, Stockholm, Sweden.ORCID 0000-0002-6428-5936
Cheng ZhangScience for Life Laboratory, KTH - Royal Institute of Technology, Stockholm, Sweden.ORCID 0000-0002-3721-8586
Zhengtao LiuScience for Life Laboratory, KTH - Royal Institute of Technology, Stockholm, Sweden.
Martina KlevstigDepartment of Molecular and Clinical Medicine, University of Gothenburg and Sahlgrenska University Hospital, Gothenburg, Sweden.
Bani MukhopadhyayLaboratory of Physiologic Studies, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD, USA.
Mattias BergentallDepartment of Molecular and Clinical Medicine, University of Gothenburg and Sahlgrenska University Hospital, Gothenburg, Sweden.
Resat CinarLaboratory of Physiologic Studies, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD, USA.ORCID 0000-0002-8597-7253
Marcus StåhlmanDepartment of Molecular and Clinical Medicine, University of Gothenburg and Sahlgrenska University Hospital, Gothenburg, Sweden.
Natasha SikanicScience for Life Laboratory, KTH - Royal Institute of Technology, Stockholm, Sweden.
Joshua K ParkLaboratory of Physiologic Studies, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD, USA.
Sumit DeshmukhScience for Life Laboratory, KTH - Royal Institute of Technology, Stockholm, Sweden.
Azadeh M HarzandiScience for Life Laboratory, KTH - Royal Institute of Technology, Stockholm, Sweden.
Tim KuijpersScience for Life Laboratory, KTH - Royal Institute of Technology, Stockholm, Sweden.
Morten GrøtliDepartment of Chemistry and Molecular Biology, University of Gothenburg, Gothenburg, Sweden.
Simon J ElsässerDepartment of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden.
Brian D PieningDepartment of Genetics, Stanford University, Stanford, CA, USA.
Michael SnyderDepartment of Genetics, Stanford University, Stanford, CA, USA.
Ulf SmithDepartment of Molecular and Clinical Medicine, University of Gothenburg and Sahlgrenska University Hospital, Gothenburg, Sweden.
Jens NielsenScience for Life Laboratory, KTH - Royal Institute of Technology, Stockholm, Sweden.ORCID 0000-0002-9955-6003
Fredrik BäckhedDepartment of Molecular and Clinical Medicine, University of Gothenburg and Sahlgrenska University Hospital, Gothenburg, Sweden.
George KunosLaboratory of Physiologic Studies, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD, USA.
Mathias UhlenScience for Life Laboratory, KTH - Royal Institute of Technology, Stockholm, Sweden.ORCID 0000-0002-4858-8056
Jan BorenDepartment of Molecular and Clinical Medicine, University of Gothenburg and Sahlgrenska University Hospital, Gothenburg, Sweden jan.boren@wlab.gu.se adilm@scilifelab.se.ORCID 0000-0003-0786-8091
Adil MardinogluScience for Life Laboratory, KTH - Royal Institute of Technology, Stockholm, Sweden jan.boren@wlab.gu.se adilm@scilifelab.se.ORCID 0000-0002-4254-6090
Science for Life Laboratory · SESahlgrenska University Hospital · SENational Institutes of Health · USStanford University · USKarolinska Institutet · SEUniversity of Gothenburg · SE

Funding

Endocannabinoids And Energy HomeostasisZIAAA000350 · NIAAA · NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM · PI KUNOS, GEORGE · 2009 to 2025
$28.4M
Special EquipmentP50HG007735 · NHGRI · STANFORD UNIVERSITY · PI CHANG, HOWARD Y · 2014 to 2018
$15.2M
NHGRI NIH HHS P50 HG007735
6 · The paper itself

Abstract

We performed integrative network analyses to identify targets that can be used for effectively treating liver diseases with minimal side effects. We first generated co-expression networks (CNs) for 46 human tissues and liver cancer to explore the functional relationships between genes and examined the overlap between functional and physical interactions. Since increased

Indexed as

Gene Regulatory NetworksAnimalsCarcinoma, HepatocellularCells, CulturedFatty Acid Synthase, Type IGene Expression ProfilingGene Expression RegulationHep G2 CellsHumansK562 CellsLiverLiver NeoplasmsMiceMolecular Targeted TherapyNon-alcoholic Fatty Liver DiseaseOrgan SpecificityFASN protein, humanFatty Acid Synthase, Type Ico‐expressionco‐regulationHCCmetabolismNAFLD

Identifiers

PMID28827398
PMCPMC5572395
OpenAlexW2749689006

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.