Evidence map›Paper›PMID 28827348›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2017

Reversal of hyperactive Wnt signaling-dependent adipocyte defects by peptide boronic acids.

Tianyi Zhang, Fu-Ning Hsu, Xiao-Jun Xie, Xiao Li, Mengmeng Liu, Xinsheng Gao, Xun Pei, Yang Liao, Wei Du, Jun-Yuan Ji

Open access · bronzeAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
0.4field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 14 citations in OpenAlex.

  1. Developmental patterning of adipose tissue bybioRxiv : the preprint server for biology · 2026
    Article
  2. Article
  3. Review
  4. Wnt/Wingless signaling promotes lipid mobilization through signal-induced transcriptional repression.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  5. Review
  6. Article
  7. Mitophagy in Diabetic Cardiomyopathy: Roles and Mechanisms.Frontiers in cell and developmental biology · 2021
    Review
  8. Metabolic Contributions of Wnt Signaling: More Than Controlling Flight.Frontiers in cell and developmental biology · 2021
    Review
  9. Article
  10. Review
  11. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Tianyi ZhangBen May Department for Cancer Research, The University of Chicago, Chicago, IL 60637.
Fu-Ning HsuDepartment of Molecular and Cellular Medicine, College of Medicine, Texas A&M University Health Science Center, College Station, TX 77843.
Xiao-Jun XieDepartment of Molecular and Cellular Medicine, College of Medicine, Texas A&M University Health Science Center, College Station, TX 77843.
Xiao LiDepartment of Molecular and Cellular Medicine, College of Medicine, Texas A&M University Health Science Center, College Station, TX 77843.
Mengmeng LiuDepartment of Molecular and Cellular Medicine, College of Medicine, Texas A&M University Health Science Center, College Station, TX 77843.
Xinsheng GaoDepartment of Molecular and Cellular Medicine, College of Medicine, Texas A&M University Health Science Center, College Station, TX 77843.
Xun PeiBen May Department for Cancer Research, The University of Chicago, Chicago, IL 60637.
Yang LiaoBen May Department for Cancer Research, The University of Chicago, Chicago, IL 60637.
Wei DuBen May Department for Cancer Research, The University of Chicago, Chicago, IL 60637; wei@uchicago.edu ji@medicine.tamhsc.edu.
Jun-Yuan JiDepartment of Molecular and Cellular Medicine, College of Medicine, Texas A&M University Health Science Center, College Station, TX 77843 wei@uchicago.edu ji@medicine.tamhsc.edu.ORCID 0000-0002-4483-4336
Texas A&M Health Science Center · USUniversity of Chicago · US

Funding

Resource Component: Acquisition, maintenance and distribution of Drosophila stocksP40OD018537 · OD · TRUSTEES OF INDIANA UNIVERSITY · PI Annette L. Parks · 2014 to 2026
$13.5M
A novel approach to target Rb mutant cancersR01CA149275 · NCI · UNIVERSITY OF CHICAGO · PI DU, WEI · 2011 to 2015
$1.6M
Context-specific Functions of CDK8R01DK095013 · NIDDK · TEXAS A&M UNIVERSITY HEALTH SCIENCE CTR · PI JI, JUN-YUAN · 2013 to 2017
$1.5M
Regulation of EGFR Signaling in the Drosophila developmentR01GM120046 · NIGMS · UNIVERSITY OF CHICAGO · PI DU, WEI · 2016 to 2019
$1.3M
NCI NIH HHS R01 CA149275NIDDK NIH HHS R01 DK095013NIGMS NIH HHS R01 GM120046NIH HHS P40 OD018537
6 · The paper itself

Abstract

Deregulated Wnt signaling and altered lipid metabolism have been linked to obesity, diabetes, and various cancers, highlighting the importance of identifying inhibitors that can modulate Wnt signaling and aberrant lipid metabolism. We have established a

Indexed as

AdipocytesAnimalsAxin Proteinbeta CateninBoronic AcidsDrosophilaPeptidesTranscription, GeneticUp-RegulationWnt ProteinsWnt Signaling PathwayAxin Proteinbeta CateninBoronic AcidsPeptidesWnt ProteinsadipocyteaxincateninDrosophilapeptide boronic acid

Identifiers

PMID28827348
PMCPMC5594642
OpenAlexW2745635694

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.